A Practical Guide To Sublingual Absorption
The goal of sublingual absorption is to get substances (ie. SARMs) into systemic circulation and delivered to target organs (ie. muscles and bones) without first passing through the liver. This is advantageous since liver metabolism is destructive—it modifies biologically-active substances in ways that can reduce their function.
Every substance that is absorbed in the gastrointestinal tract passes through the liver before it gets distributed throughout the body. To bypass this “first-pass effect”, follow these steps:
- Step 1. Using the dropper, measure your Poly-Cell Formula and deposit it under your tongue.
- Step 2. Leave it under your tongue for 1-2 minutes without swallowing. Keep your head tilted slightly back to prevent saliva from pooling in your mouth.
- Step 3. After 1-2 minutes, you can swallow to clear out your mouth, but avoid drinking anything for at least 10 minutes in order to allow any residual Poly-Cell Formula to fully absorb in your mouth, throat and upper esophagus.
Whenever you swallow a small amount of saliva, it generally does not reach your stomach because it forms a thin film that lines your throat and esophagus. Substances that get absorbed into the upper half of your esophageal tissue get carried by esophageal veins to the superior vena cava, which bypasses first-pass metabolism in your liver. However, if you drink anything soon after swallowing residual Poly-Cell formula, it will wash down to your stomach and defeat the purpose. It will still be effective, but likely not as potent.