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SARMS – An Updated Overview

SARMs (Selective Androgen Receptor Modulators) are a class of medicinal agents with anabolic effects similar to anabolic steroids but with less androgenic (male-like) features. Both function by connecting to androgen receptors in your body, causing DNA modifications that enhance your muscles’ capacity to expand.

It may be beneficial in clinical settings for promoting particular tissue formation, such as muscle and bone, as well as preventing adverse side effects in other organs, such as the liver and skin.

Scientists are still studying SARMs as a therapeutic cure for muscle wasting triggered by various diseases, including osteoporosis, chronic liver failure, cardiac failure, cancer, end-stage kidney disease, chronic obstructive pulmonary disease (COPD), and HIV.

In addition, rather than being injected, they are taken as pills, orally or in some other sublingual fashion. What are the drawbacks? The FDA has not given any of them the green light to be consumed by humans.

Researchers created SARMs intending to maximize testosterone’s benefits while mitigating its downside.

When medically indicated, physicians currently administer testosterone and associated steroids to stimulate anabolic development, and they are effective. Still, in most instances, it’s like using a sledgehammer to drive a nail in. It’s just not the best tool for the task, and you could ruin something else as a result.

Online searches for SARMs that include andarine and ostarine have gradually increased over the last five years. London’s famous “Fatberg,” the mass of oil and organic matter found in the capital’s sewers, contained SARMs in greater concentrations than MDMA and cocaine, but there’s no way of tracking how many people are buying them.

SARMs vs. Anabolic Steroids

SARMs are rare compounds that scientists have extensively researched as a means of androgen therapy and testosterone replacement. Although similar treatments have been around for a long time, they have primarily focused on anabolic steroids.

Anabolic steroids are blunt, binding to androgen receptors in several tissues of the body. They can affect other areas of the body, causing adverse effects including:

  • Prostate problems
  • Hair loss
  • Acne
  • Male breast growth
  • Aggression and mood disorders, liver toxicity
  • Heart disease

The idea that anabolic steroids improve androgen signaling in your whole body is the cause of these side effects. They work similarly to SARMs in that they attach to androgen receptors in your cells, causing muscle hypertrophy. As a result, the outcomes are both solid and widespread, potentially leading to the long-term health consequences mentioned above.

Unlike steroids, Individual SARMs selectively target the androgen receptors in your bone and muscle tissues instead of generating a full-body reaction. This aids in the protection of your cardiovascular systems and prostate. SARMs are not labeled as steroids since they lack the same molecular ring form.

The absence of the steroidal ring formation is essential, as it describes why SARMs function the way they do. Consider the fact that we can transform testosterone into estradiol, an estrogen-like substance. We cannot convert SARMs that aren’t steroidal the same way. As a result, SARMs are well-positioned to treat a variety of diseases.

The idea behind this process is simple: SARMs can cause targeted tissues to respond similarly to testosterone or another anabolic steroid. On the other hand, other tissues that could have unfavorable side effects if targeted are not triggered in the same way.

Theoretically, this allows for the same effects as traditional testosterone treatment while avoiding much of the complications.

Is It Legal To Buy SARMs?

Congress debated the SARMs Control Act in 2019, which was introduced to Congress in the previous year. The act aims to classify SARMs as controlled drugs. But for the second year in a row, Congress refused to go ahead with the proposal, and as a result, there are currently no rules banning the possession of SARMs in the United States.

It’s not surprising that several US-based businesses have sprung up to meet the increasing demands. Some companies, perhaps fearful of the consequences of marketing unlicensed drugs, use legitimate disclaimers to describe the products as “research laboratory chemicals.”

Anabolic agents (such as testosterone and human growth hormone), on the other hand, are also Schedule III controlled drugs, which implies that, unlike SARMs, their possession is prohibited.

Of course, the legality of SARMs would almost inevitably shift with time, but for the time being, Congress has chosen to delay rather than deal with the issue. Regardless, SARMs are only available for research, and people should not market them as dietary supplements.

We can expect a few SARMs to be FDA-licensed for some medical indications in the future. But this will only happen after they have conducted satisfactory Phase III clinical trials, which is likely to take a few years.

Enobosarm is the only SARM that has come closest to approval from the FDA. It completed a few Phase III trials that yielded a combination of positive and negative news.

The positive news was that it resulted in increased lean body mass than placebo. The bad news was that, amid these encouraging findings, the study struggled to achieve its main objectives, keeping cancer patients from losing weight and physical activity.

Unfortunately, suppose a drug trial fails to reach its primary endpoints. In that case, the FDA is reluctant to approve it, even when the experiment showed that Enobosarm was non-toxic, well absorbed, and improved lean body mass compared to placebo.

Many companies that sell SARMs caution potential consumers that they do not sell the products for human consumption. That is enough to offer you some food for thought.

The US regulators launched a ban on SARMs in 2017. The head of the FDA’s Center for Drug Evaluation and Research shared concerns about the shady companies selling body-building medical products containing potentially dangerous ingredients. He cautioned that SARMS could be associated with significant health issues, including increased risk of stroke or heart attack and life-threatening reactions such as liver damage.

Origin of SARMs

The discovery of SARMs was a mere accident. Professor James T Dalton focused on pioneering therapies for prostate cancer in the early 1990s when he discovered the molecule andarine, the first SARM.

It had no impact on prostate cancer treatment, but it significantly influenced muscle development. Dalton told Men’s Health, “It was the complete opposite of what we were hoping for at the moment. However, we focused almost entirely on this because we felt we have discovered something special.”

Dalton went on to develop a more advanced form, known as ostarine, a few years later. During clinical trials, older men offered a 12-week course of the medication gained more than a 15% boost in stair climb strength while still increasing lean muscle mass and reducing fat.

The researchers suspended the drug’s production when a subsequent study in cancer patients struggled to yield the expected outcomes. Since then, Dalton has attempted to stop the businesses profiting off his inventions on the black market.

He sent several cease and desist letters to a few of them and contacted the FDA to close them down, but all efforts proved abortive. There was nothing they could do to control it.

Why Do SARMs Generate Such Interest?

We can attribute the high level of interest in SARM research among scientists to a few factors. First, it has broad potential clinical indications, including breast cancer, prostate cancer, muscular dystrophy, dementia, and osteoporosis.

Secondly, all of the SARM clinical studies that researchers have conducted have yielded positive outcomes, with good tolerability and few side effects. However, this would not rule out the possibility of SARMs posing a danger since you can only determine medication safety over time, in several clinical trials, often in hundreds or thousands of patients.

SARM testing hasn’t gone far enough to allow large reliability claims, but we’re far on our way there.

Finally, society would be burdened by an aging population soon. Unfortunately, lifespans do not necessarily correspond to a high level of wellbeing. Muscle and bone deterioration develop when men and women mature, resulting in a lack of stamina, balance, and agility. Hence, this raises the likelihood of a catastrophic slip and fall, resulting in a hip injury and driving a loved one into costly long-term treatment.

Physicians anticipate that SARMS would aid in the prevention of muscle and bone deterioration and increase the health of our elderly society, allowing more individuals to age independently until their golden years.

Furthermore, several newer SARMS, such as NEP28, are being researched for their ability to cure Alzheimer’s disease, an increasing concern in the elderly.

Finally, in middle-aged adults, SARMS could be a viable option for testosterone replacement therapy (TRT). Currently, physicians use testosterone to treat signs of andropause such as muscular stiffness, nausea, loss of muscle mass, osteoporosis, sexual dysfunction, exhaustion, insomnia, and memory loss.

Patients can choose SARMs since they are orally bioavailable and can be taken as pills, contributing to greater compliance relative to testosterone injections. Furthermore, although TRT usually is well-tolerated, testosterone supplementation has several common side effects, including the acceleration of pre-existing prostate cancer development.

Future clinical studies of SARMS are expected to assess these criteria in men being treated for low testosterone, positioning SARMS as a superior option to traditional androgen therapy.

Benefits of SARMs

SARMS are known to have no toxic effects on the human liver and to have a minor impact on the body’s blood pressure. As a result, the requirement for preloading supplements and on-cycle support is no longer needed. In comparison to the standard AAS/Ph loop, the SARMs cycle is often less costly.

Let’s take a quick look at why some consumers buy SARMs frequently marketed as research chemicals or dietary supplements.

Ligandrol (LGD 4033)

The LGD 4033 is functionally similar to ostarine but 12 times more potent. It plays a critical role in the body’s immune and reproductive systems’ control and growth. People may also use it as a bulking agent. As a result, health professionals recommend it to fitness enthusiasts and bodybuilders.

LGD4033 Anabolicum Ligandrol

This one is still in clinical trials, but it is supposed to be effective in preventing muscle atrophy. It is also thought to be effective for soft tissues, bone health, and joints. Athletes prefer it because it makes them develop lean muscle mass even with a daily dosage of 5-20 mg.

MK2866 Ostarine Ostabolic

It is still under clinical tests for bone health and muscle wasting. Athletes may use it to increase strength, build lean muscles, and heal joints. The average daily dosage would be in the range of 20-25 mg.

S4 Andarine

Pharmaceutical companies hope that this class of SARMs can aid in the management of prostate issues. Fitness enthusiasts also use it to build lean muscles, gain stamina, and lose weight. The usual daily dosage ranges from 25-100 mg.

GW501516 Cardarine & SR9009 Stenabolic

Both are believed to aid in removing body fat and the enhancement of stamina, and they are safe for usage at any time since they’re not hormonal.

MK677 Nutrobal – Ibutamoren

It’s also known as a growth hormone secretagogue, meaning it will further increase the release of growth hormone and IGF-1 in the body.

It has a lot of benefits, including an improvement in appetite and improved sleep quality. Over time, you will notice that you are healing more quickly, losing bodyweight, and increasing the body’s lean muscle mass. It’s not suppressive, so it’s perfectly safe to use.

RAD140-Testolone

This group of SARMs is expected to substitute for anabolic hormones used in replacement therapy. It is the most efficient of all and will aid in developing lean muscle mass, weight, and bone health. The regular dose is typically around 10-20mg.

It is important to understand your body first before choosing which SARMs to buy. When using these research compounds, we recommend that you go for Post Cycle Therapy (PCT). 

Unique Benefits for Women

Women with low testosterone would notice that steroid therapy makes them sound unfeminine and gives them a louder voice than average. One of the potential benefits, as found in clinical studies of SARMs, is that they do not cause virilization in women.

These research compounds are tissue-specific, targeting both the bones and muscles, which is excellent news for women since they’re more likely than men to experience osteoporosis as they age.

Osteoporosis affects an estimated ten million Americans, with women accounting for 80 percent of the cases. According to the National Osteoporosis Foundation, a woman’s chance of losing her hip is equivalent to her absolute risk of uterine, breast, and ovarian cancer.

SARMs treatment allows women and men to pursue a targeted path to improving their bones and muscles simultaneously.

Side Effects of SARMs

The FDA warned consumers regarding potential fatal side effects of SARMs such as heart attack and stroke. While some people experience increased strength, many often seek help on issues related to impotence, skin rashes, and high blood pressure.

Eye problems tend to be especially common; andarine may tint users’ vision green or yellow. Side effects may vary among users, therefore, consult your doctor before buying or using it. 

Why Does SARMs Quality Matter?

You’ll find that there are several places you can buy SARMs when you search the internet. But why does it matter where you buy SARMs?

Verifying your supplier might be the difference between buying a clean, undiluted, and high-quality research compound. Buying SARMs from reliable suppliers will help you avoid the side effects of diluted or fake ones, allowing you to get the most out of your investment.

Although there are several trustworthy outlets, the sad fact is that there are still unscrupulous crooks who would sell a tainted product for personal gain. You can quickly discern the viable vendors with a bit of time and diligence.

Are SARMs on the Prohibited List of the World Anti-Doping Agency (WADA)?

It doesn’t matter if you’re in or out of competition; WADA prohibits all SARMs for athletes, including those participating at the sport level and those participating at leisure and recreational level. WADA classified SARMs in their prohibited list as “Other Anabolic Agents.”

Owing to SARMS’ anabolic properties, and their capacity to activate androgen receptors in muscle and bone, they can potentially be abused for performance enhancement in sports.

Can Doctors Prescribe SARMs?

No. Presently, there are no SARMs approved by the FDA for prescription. Since every type of SARM is an  investigational new drug, your doctor is not allowed to prescribe one. Athletes interested in participating in clinical trials concerning prohibited drugs can apply for Therapeutic Use Exemption (TUE) from the United States Anti-Doping Agency (USASA).

Conclusion

Authorities still consider SARMs as test compounds, which is why the market remains unregulated. There are a lot of low-quality and counterfeit products all over the place. Purchasing counterfeits may be very dangerous.

SARMs do have a lot of health benefits. However, this would not remove the idea that it may have harmful side effects. As a result, you must be mindful of these when incorporating them into your everyday routine. If you want to give it a shot, make sure you speak to the doctor first. 

What are SARMs

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