BROMANTANE

Description

Bromantane

 

 

 

Molecular Formula	C₁₆H₂₀BrN
Molecular Weight	306.24
Purity	≥99% Pure (LC-MS)
Storage	Store in cool dry environment, away from direct sunlight.
Terms	Lab Use Only. This information is for educational purposes only and does not constitute medical advice.

 

Characteristics of Bromantane

Bromantane is a nootropic compound that was developed in Russia in 1980 known to have potent psychostimulatory and anxiolytic effects. It is considered a part of the adamantane family and is closely related to both memantine and amantadine. Bromantane is considered an actoprotector, meaning it plays a vital role in is enhancing physical performance in extreme environmental conditions. In addition to its psychostimulatory and anxiolytic effects, the compound has been found to inhibit fatigue, improve coordination, and promote learning.
It has also shown promise increasing the expression of various genetics in rats such as HIF1A, which allows for adaptation to low oxygen levels, and ADRI, which helps with recovery from alcohol.

Generally, bromantane works by increasing brain activity. The compound works through the dopaminergic system by increasing the activity of tyrosine hydroxylase and decarboxylase. This allows for increased production of dopamine through the activation of tyrosine. Additionally,
bromantane is involved in increasing levels of serotonin in the brain. Bromantane’s ability to increase dopamine and serotonin production leads to feelings of happiness and an increase in energy and alertness (https://selfhacked.com/blog/bromantane/).

 

Uses for Bromantane

In addition to the benefits mentioned above, one of the primary uses for bromantane is to treat the disorder neurasthenia. Neurasthenia is similar to a sleep disorder as one of the main side effects is insomnia. In addition to insomnia, side effects include brain fog, fatigue, and headaches. A notable study conducted in Russia by Vosnesenskaia et. Al, tested the effects of bromantane against neurasthenia with both 50 and 100 mg doses. The study occurred over a one month period of time and utilized 728 test subjects. The results concluded that administration of bromantane helps to reduce the symptoms of neurasthenia and improve overall quality of life in the subjects receiving both the 50 and 100 mg doses. Furthermore, it was found that bromantane is generally well tolerated as only 3% of the subjects experienced any side effects of the compound.

Additional studies in neurasthenia patients examined how bromantane was capable of affecting brian activity. Results of this study conducted by Neznamov et. Al reported that subjects experiencing high alpha brain waves also had increased levels of low-beta waves and decreased
levels of high-beta waves. The opposite was found to be true in subjects experiencing low alpha brain waves. This relationship between the alpha and beta brain waves indicates that treatment with bromantane could decrease drowsiness and improve energy levels.

Evidence shows that bromantane has many other beneficial effects such as the improvement of brain functioning and physical activity as well as the reduction of inflammation. In regards to brain functioning, researchers Iezhitsa et. Al examined how varying doses affected behavioral activity in rats. Doses of 30-300 mg/kg were found to stimulate behavioral activity while doses 300-600 mg/kg suppressed behavioral activity. Additionally, spontaneous motor activity was increased in doses from 30-300 mg/kg and inhibited in doses above 600 mg/kg. Pain sensitivity was decreased in doses ranging from 300-600 mg/kg while the pain threshold was increased in doses above 600 mg. These reported results indicate that the beneficial effects of bromantane work in a dose-dependent manner. The researchers found that any behavioral changes were due to the stimulation of the dopaminergic systems and the suppression of nicotinic cholinergic and muscarinic structures (https://pubmed.ncbi.nlm.nih.gov/12124651/).

As bromantane works primarily through the dopaminergic system, evidence has found that the compound is capable of reducing inflammation that is specifically related to depression. Administration of bromantane leads to the reduction of inflammatory markers such as IL-6, IL-17, IL-4, and TNF-𝞪.

Bromantane has also shown promise in improving physical activity by increasing levels of epinephrine and norepinephrine. It allows for them to stay in the bloodstream for longer periods of time rather than being excreted. Furthermore, mice and rats were given bromantane in doses varying from 0.50-50 mg/kg, followed by swimming and treadmill tests. In comparison to another popular enhancement compound, phenamine, bromantane was found to be 1.3-1.6 times more effective when both supplements were administered in optimal doses.

Essentially, bromantane works to delay the decrease of physical performance while restoring it faster and more efficiently. This was supported by the successful results of the repeated treadmill tests the mice and rats completed. The compound was also found to prevent changes of the electrons found in cardiomyocytes and myocyte mitochondria of skeletal muscles. Researchers were able to conclude that bromantane improves physical activity not only through its notable psychostimulatory effects related to brain functioning, but also through
membrane-protective effects (https://pubmed.ncbi.nlm.nih.gov/9929819/).

The nootropics sold by Umbrella Labs are sold for laboratory research only. The description above is not medical advice and is for informative purposes only.

All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

 

Bromantane is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

 

 

 

 

File Name	View/Download
01-27-2023-Umbrella-Labs-Bromantane-Certificate-Of-Authenticity-COA.pdf

 

 

VIEW CERTIFICATES OF AUTHENTICITY (COA)

 

 

Additional information

Weight	10 Grams, 5 Grams