Description

NMN (Nicotinamide Mononucleotide) Nootropic Powder

 

 

 

CAS Number	1094-61-7
Other Names	Nicotinamide Mononucleotide, 1094-61-7, Beta-Nicotinamide Mononucleotide, Nicotinamide Ribotide, NMN zwitterion, beta-NMN
IUPAC Name	[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
Molecular Formula	C₁₁H₁₅N₂O₈P
Molecular Weight	334.22
Purity	≥99% Pure (LC-MS)
Liquid Availability	N/A
Powder Availability	15 grams, 30 grams
Gel Availability	N/A
Storage	Store in cool dry environment, away from direct sunlight.
Terms	All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

 

Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide. In the body NMN is converted into the molecule nicotinamide adenine dinucleotide (NAD). NAD is crucial to many of the biological pathways related to energy production and metabolism, such as the cyclic acid cycle and the electron transport chain. NAD helps to regulate essential cellular functions. Utilization of NAD is based solely on the amount of NMN available, emphasizing the importance of its presence.

NMN levels tend to decrease with advanced age which results in a decrease in NAD and many residual side effects and potential health conditions. That being said, many of the known benefits of NMN supplementation are related to improved longevity and health. What’s interesting about this compound is that the observed benefits are related to NAD levels. However, as NAD has no way of passing through the cellular membrane the effects are elicited primarily by the conversion of NMN into NAD within the cells.

The majority of mammals tend to synthesize NMN from vitamin B3 in the form of nicotinamide. The key player in this reaction is the rate-limiting enzyme, nicotinamide phosphoribosyltransferase (NAMPT), which catalyzes the conversion of nicotinamide to NMN. NAMPT exists in both extracellular (eNAMPT) and intracellular (iNAMPT). However, eNAMPT is known for its higher enzymatic activity and wide availability as it is produced by fat cells, liver cells, white blood cells, heart cells, and brain cells.

Research has found that both brown and white adipose tissue actively secrete high levels of eNAMPT, indicating that adipose tissue may play a role in the regulation of NAD. In addition to secreting eNAMPT, adipose tissue has been shown to secrete extracellular vesicles (EVs) that can circulate through plasma. The performance of these EVs is found to be improved by the presence of NMN. Recent studies have identified an enzyme, Slc12a8, that is capable of transporting NMN through the cellular membrane directly into the cytoplasm. While EVs and eNAMPT are primarily secreted by adipose tissue, secretion of Slc12a8 is found to be 100 times higher in the small intestine. That being said, researchers have hypothesized that the gut microbiome could play a role in the production of NMN.

Effects of NMN on Anti-Aging and Overall Health

NMN is frequently referred to as the “fountain of youth” compound as many mouse models have emphasized the ability of NMN to enhance metabolism and performance, improve insulin sensitivity, and protect against ischemia and reperfusion injury. Specifically in terms of aging, NMN reduces the likelihood for age-related weight gain, restores skeletal muscle in aged mice, and inhibits age-related changes in gene expressions. Additionally, research has found that NMN reduces age-related increases in inflammation, also referred to as, inflammaging.
This is primarily due to NMN decreasing adipose tissue inflammation in aged mice. In fact, the cited study claims that older mice are often more receptive to the benefits of NMN than young mice are, in fact subjects exhibited higher energy levels and less fatigue when orally administered NMN (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238909/)

Further animal-based studies examined how irregular biosynthesis of NAD can lead to obesity and metabolic abnormalities such as insulin resistance. These studies report that since NMN is directly related to NAD, supplementation of NMN can lead to reduced rates of obesity and improved glucose tolerance and insulin sensitivity. Researchers Yoshino et. Al honed in their experimental groups and focused on the benefits of NMN in postmenopausal, prediabetic, overweight animals. The study included 25 test subjects. 12 of which were given a placebo while the remaining 13 received active NMN.

The study took place over a 10-week time period where each subject was given the same dose of either NMN or a placebo every day. Administration of NMN was seen to increase rates of insulin-stimulated glucose disposal which was measured through the hyperinsulinemic-euglycemic clamp. Additionally, by tracking the phosphorylation of AKT and mTOR, researchers were able to observe that NMN led to improvement of skeletal muscle insulin signaling. Results also reported that supplementation with NMN led to upregulated expression of various genes related to muscle remodeling, such as platelet-derived growth factor receptor 𝜷. Based on these results, the researchers were able to conclude that by administering NMN insulin sensitivity and skeletal muscle remodeling was improved specifically in prediabetic and overweight female subjects (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550608/).

The nootropics sold by Umbrella Labs are sold for laboratory research only. The description above is not medical advice and is for informative purposes only.

NMN (NICOTINAMIDE MONONUCLEOTIDE) is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

 

File Name	View/Download
10-02-2020-NMN-Certificate-of-Analysis-COA.pdf

 

 

VIEW CERTIFICATES OF ANALYSIS (COA)

 

 

Additional information

Weight	15 Grams, 30 Grams