Main Research Findings on Bromantane

1. Bromantane is capable of manipulating behavior in a dose-dependent manner by changing expression of dopamine, muscarinic, and cholinergic receptors

2. Bromantane is able to improve physical performance by increasing epinephrine and noradrenaline.

Selected Data

1. Experiments were conducted with 200 male or female adult albino rats, ranging from 150-200 grams in weight. Bromantane was administered to the rat in increasing doses ranging from 30-9600 mg/kg. 5 male and 5 female rats were separated into groups while the effects of bromantane were measured by observing behavioral activity, spontaneous motor activity, and pain sensitivity. After bromantane was administered the animals were monitored for 12 hours straight. This examination occurred daily over the course of 2 weeks.

2. Random-bred mice and rats were categorized into two groups and administered varying doses of 0.5-50 mg/kg of bromantane or phenamine, another popular enhancement compound. The mice and rats underwent a swimming test and a treadmill test in order to observe changes in their physical performance and compare the two compounds. Additionally, the researchers compared the improvement in physical ability to changes in epinephrine and noradrenaline levels.

Discussion

1. Evidence shows that bromantane has many other beneficial effects such as the improvement of brain functioning and physical activity as well as the reduction of inflammation. In regards to brain functioning, researchers Iezhitsa et. Al examined how varying doses of 30-300 mg/kg were found to stimulate behavioral activity while doses 300-600 mg/kg suppressed behavioral activity. Additionally, spontaneous motor activity was increased in doses from 30-300 mg/kg and inhibited in doses above 600 mg/kg. Pain sensitivity was decreased in doses ranging from 300-600 mg/kg while the pain threshold was increased in doses above 600 mg. These reported results indicate that the beneficial effects of bromantane work in a dose-dependent manner. The researchers found that any behavioral changes were due to the stimulation of the dopaminergic systems and the suppression of nicotinic cholinergic and muscarinic structures [2].

Figure 1: Parameter changes depending on bromantane dosage

2. Bromantane has also shown promise in improving physical activity by increasing levels of epinephrine and norepinephrine. It allows for them to stay in the bloodstream for longer periods of time rather than being excreted. Following administration of bromantane in doses varying from 0.5-50 mg/kg, the compound was found to be 1.3-1.6 times more effective than similar popular enchantment compound, phenamine, when administered in optimal doses.

Essentially, bromantane works to delay the decrease of physical performance while restoring it faster and more efficiently. This was supported by the successful results of the repeated treadmill tests the mice and rats completed that corresponded with increased levels of epinephrine and noradrenaline. The compound was also found to prevent changes of the electrons found in cardiomyocytes and myocyte mitochondria of skeletal muscles. Researchers were able to conclude that bromantane improves physical activity not only through its notable psychostimulatory effects related to brain functioning, but also through membrane-protective effects [3].

Conclusion

**LAB USE ONLY**
*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

Citations

[1] Cohen, Joe, and Jonathan Ritter. “6 Uses of Bromantane (Ladasten) + Side Effects – SelfDecode Drugs.” Drugs, 15 December 2022, https://selfhacked.com/blog/bromantane/. Accessed 17 April 2023.

[2] Iezhitsa IN, Spasov AA, Bugaeva LI, Morozov IS. Toxic effect of single treatment with bromantane on neurological status of experimental animals. Bull Exp Biol Med. 2002 Apr;133(4):380-3. doi: 10.1023/a:1016206306875. PMID: 12124651.

[3] Morozov IS, Kleĭmenova NN. Vliianie bromantana na fizicheskuiu rabotosposobnost’ laboratornykh zhivotnykh [The effect of bromantane on the physical work capacity of laboratory animals]. Eksp Klin Farmakol. 1998 Nov-Dec;61(6):51-3. Russian. PMID: 9929819.

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