Description

Pramiracetam Nootropic Powder

 

 

 

 

 

 

 

CAS Number	68497-62-1
Other Names	amacetam, Pramiracetamum, Vinpotropil, UNII-4449F8I3LE, 4449F8I3LE, Neupramir, Pramistar, CNS-1879, Ectapram
IUPAC Name	N-[2-[di(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide
Molecular Formula	C₁₄H₂₇N₃O₂
Molecular Weight	269.38
Purity	≥99% Pure (LC-MS)
Liquid Availability	30mL liquid (200mg/mL, 6000mg bottle)
Powder Availability	5 grams, 10 grams
Gel Availability	N/A
Storage	Store in cool dry environment, away from direct sunlight.
Terms	All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

 

Mechanisms of Action of Pramiracetam

Pramiracetam is a synthetically developed nootropic that shares structural similarities to the commonly known racetam compound, piracetam. Research comparing the two have found that pramiracetam requires lower doses to be considered effective and has shown to have stronger anti-amnesic effects. The compound was developed in 1984 and differs from piracetam by replacing the amide group with a dipropan-2-aminoethyl group. Research conducted on dogs has found that the half life of pramiracetam can vary from 2-8 hours depending on dosage; typical dosages range from 5-1600 mg, depending on the test subject. Similar to many other nootropic compounds, the primary goal of pramiracetam is to enhance cognitive functioning.

Despite pramiracetam’s ability to promote memory and learning, animal-based studies have found that it does not elicit significant levels of excitatory postsynaptic potentials in the hippocampus. Research has indicated that the enhancement of cognition is linked to the activity of the adrenal glands. The results reported by Mondadori et. Al found that the majority of the benefits of pramiracetam were abolished when subjects underwent an adrenalectomy. That being said, research showed that the activity of pramiracetam is potentially linked to steroid metabolism, specifically aldosterone receptors. Mondadori et. Al stated that aldosterone receptor antagonists, such as epoxymexrenone, blocked the effects of pramiracetam. Additionally, raised levels of corticosteroids tends to inhibit the activity of pramiracetam and a multitude of other racetam drugs (https://pubmed.ncbi.nlm.nih.gov/2137359/).

Further studies conducted by researchers Porschel et. Al examined the effect of pramiracetam on EEG functioning in aged rats. The minimum effective dosage ranged from 5-20 mg/kg, however, it was reported that the benefits were still seen in doses as high as 400 mg/kg. Researchers observed that treating the aged rats with pramiracetam led to the subjects acting in a manner fitting of youthful rats. When administering pramiracetam to the rats, drastic changes were seen in cortical slow waves and hippocampal theta waves. These changes were measured by tracking performance on a water maze test which indicated an improvement in overall cognitive functioning in the rats (https://pubmed.ncbi.nlm.nih.gov/4065299/).

As it was previously mentioned, the effects of pramiracetam are linked to the adrenal glands. That being said, the compound does not seem to act on dopaminergic, GABAergic, or serotonergic receptors. However, evidence has found that pramiracetam influences cholinergic neurotransmission. Doses of the compound ranging from 44-88 mg/kg were shown to increase high-affinity choline uptake (HACU) in the hippocampus of rats within 30 minutes of injection. This claim was supported by the work of Brust, P. who found that an injection of pramiracetam was able to regulate choline transport that was purposely disrupted by administering scopolamine (https://pubmed.ncbi.nlm.nih.gov/2610714/).

 

Effects of Pramiracetam on Memory

HACU is also known to be a rate-limiting step in the synthesis of acetylcholine (ACh), a neurotransmitter that is highly involved in memory retention and learning. Evidence has identified disruptions in HACU functioning in subjects with Alzheimer’s Disease and dementia. Various animal-based studies have found that the administration of cholinergic antagonists leads to different memory impairments. For example, Elvander et. Al found that infusing scopolamine into the hippocampus resulted in impaired spatial coding and reduced levels of ACh secretion. Additional research has emphasized the necessity of ACh for normal cognitive function in terms of working memory, attention, episodic memory, and spatial memory. Pramiracetam’s ability to increase HACU implies that there is increased synthesization of ACh, thus supporting the idea that pramiracetam actively works to improve cognitive function.

Many early studies supported claims that pramiracetam has anti-amnesic effects. Researchers Butler et. Al began experimentation by inducing amnesia via electroconvulsive shock (ECS) in mice. Results reported that daily administration of a 5 mg/kg dose of pramiracetam led to the reversal of amnesia with a 96% success rate with little to no incidence of side effects. Another notable study conducted by Franklin et. Al, induced amnesia through the administration of the anticholinergic toxin, hemicholinium-3 (HC-3). The mice involved were pretreated with pramiracetam 30 minutes before administration of HC-3. Results of the study reported that pramiracetam was able to effectively suppress the amnesic effects of HC-3 more efficiently than other racetams, such as piracetam. Overall, a multitude of studies report that doses of pramiracetam ranging from 5-400 mg/kg are highly capable of either reversing or reducing amnesic effects induced by different toxins (https://examine.com/supplements/pramiracetam/research/#KQeoel9-sources-and-structure-1_KQeoel9-sources-1).

The nootropics sold by Umbrella Labs are sold for laboratory research only. The description above is not medical advice and is for informative purposes only.

Pramiracetam is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

 

 

 

 

File Name	View/Download
09-21-2023-Umbrella-Labs-Pramiracetam-Certificate-Of-Analysis-COA.pdf

 

 

VIEW CERTIFICATES OF ANALYSIS (COA)

 

Additional information

Options	10 Grams Powder, 5 Grams Powder