Adipotide is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

Availability: In stock Category:
View cart




adipotide dosage adipotide dosage adipotide dosage adipotide dosage adipotide dosage adipotide dosage adipotide dosage adipotide dosage


adipotide dosage


Molecular Formula C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight 2611.41
Purity ≥99% Pure (LC-MS)
Storage Store in a dry, cool, dark place. For best preservation, store at 4°C or colder away from bright light.
Terms Lab Use Only. This information is for educational purposes only and does not constitute medical advice.


Adipotide is a ligand-directed peptide analog that is capable of mimicking the actions of natural peptides. Adipotide has been shown to reduce body fat through the mechanism of targeted apoptosis of the blood vessels found throughout adipose tissue. 


A study conducted by Barnhart et. Al, examined the activity and effectiveness of adipotide in obese rhesus macaques. The monkeys chosen for this study were all adult females ages 9 to 13, and each monkey weighed anywhere from 10.0 kg to 11.7 kg with a BMI ranging from 34 to 45. Additionally, each monkey held the extra weight primarily in the abdominal area. 


Adipotide was subcutaneously injected in increasing doses starting at 0.10 mg/kg to 0.75 mg/kg over the course of 9 weeks. With the increasing doses, the study found that adipotide was successful in reducing body weight, the circumference of the abdomen, and BMI. The two initial monkeys that received treatment saw a 1.8 kg and a 2.1 kg drop in body weight, respectively. The BMI of the morbidly obese monkey dropped 17.1% from 45 to 37.3 while the BMI of the other monkey dropped 20.4% from 38.8 to 30.9. The circumference of the abdomen also dropped significantly by 6.5 cm in the first monkey and 9.0 cm in the second monkey. 


Additionally, the experiment found the treatment with adipotide led to decreased insulin resistance. The morbidly obese monkeys were confirmed to be insulin-resistant through an intravenous glucose tolerance test. The obese monkeys seemed to have relatively normal insulin responses. Following testing with adipotide, the area under the curve regarding levels of insulin resistance decreased by 61.4% in the morbidly obese monkey and 63.5% in the obese monkey. 


Overall the study concluded that the optimal dose for adipotide in rhesus macaques was approximately 0.43 mg/kg. Through the use of DEXA scans and MRIs the researchers were able to confirm that dosing the experimental group of morbidly obese and obese monkeys with adipotide led to an overall decrease in body weight, abdominal circumference, BMI, and insulin resistance. In comparison, the control group of obese monkeys injected with saline did not see a change in any of the measured variables. 


It should be noted that throughout the 9 weeks of subcutaneous treatment with adipotide, the monkeys remained alert and did not experience any kind of nausea, vomiting, or aversion to food. Both the experimental group and the control group ate primate biscuits and enrichment supplements, and each meal and the amount of food eaten were documented in order to show that there was no extreme change in appetite when testing with adipotide (  


Peptides Prefer the Cold

In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.

Swab the top of the vial with a 95% alcohol wipe before accessing.

Only Mix with Sterile Bacteriostatic Water

Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.

Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.

Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.


Prohibitin-targeting peptide 1 (also known as prohibitin-TP01 and TP01; trade name Adipotide) is a peptidomimetic with sequence CKGGRAKDC-GG-D(KLAKLAK)2. It is an experimental proapoptotic drug[1] that has been shown to cause rapid weight loss in mice[2] and rhesus monkeys.[3] Its mechanism of action is to target specific blood vessels supplying adipose tissue with blood, cause the vessels to shrink and the fat cells fed by those vessels to undergo apoptosis.[4] TP01 is designed to bind to two receptors, ANXA2 and prohibitin, that are specific to blood vessels supplying white adipose tissue.[5]

Adipotide Peptide is under active investigation in a number of cell culture and animal models.
Our Adipotide Peptide is stored and handled according to industry guidelines to ensure stability.


Keep peptide vials refrigerated at all times to reduce peptide bond breakdown. DO NOT FREEZE. Most peptides, especially shorter ones, can be preserved for weeks if careful.
Always swab the top of the vial with an alcohol wipe, rubbing alcohol or 95% ethanol before use.
Before drawing solution from any dissolved peptide vial, fill the pin with air to the same measurement you will be filling with solution, ie. if you plan to take 0.1 ml, first fill the pin with 0.1ml of air, push the air into the vial, and then draw the peptide back up to the 0.1 ml marker. Doing so will maintain even pressure in the vial. Always remember to remove air bubbles from the pin by flicking it gently, needle side up, and pushing bubbles out. In addition, push out a tiny amount of solution to ensure there is no air left in the metal tip.


The purity and sterility of bacteriostatic water are essential to prevent contamination and to preserve the shelf-life of dissolved peptides.
Push the pin through the rubber stopper at a slight angle, so that you inject the bacteriostatic water toward the inside wall of the vial, not directly onto the powder.
Lyophilized peptide should be stored at -20°C (freezer), and the reconstituted peptide solution at 4°C (refrigerated). Do not freeze once reconstituted.


Air bubbles are unfavorable to the stability of proteins.
adipotide dosage adipotide dosageadipotide dosage
Adipotide for saleAdipotide for saleAdipotide for sale
Peptide Purity Chart
Adipotide Peptide Certificate of Authenticity COA