CJC-1295 DAC PEPTIDE 2MG/5MG VIAL

$34.99$79.99

CJC-1295 DAC is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

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Description

CJC-1295 DAC

 

 

 

Molecular Formula C₁₅₄H₂₅₆N₄₄O₄₄
Molecular Weight 3427.9
Purity ≥99% Pure (LC-MS)
Storage Store in a dry, cool, dark place. For best preservation, store at 4°C or colder away from bright light.
Terms Lab Use Only. This information is for educational purposes only and does not constitute medical advice.

 

The release of growth hormone (GH) is effectively stimulated by supplementation of the peptide CJC-1295. The C-terminus of CJC-1295 has a covalent addition of maleimidopropionic acid group which is what adds to the unique properties of the compound. By addition the covalent attachment to the C-terminus, the compound is able to easily bind to plasma proteins, CJC-1295 most commonly binds to albumin. With the covalent conjugation of the compound to albumin, the peptide has been shown to have a longer half-life.

 

Effects of CJC-1295 on Mice with GHRH Knockout Gene

In a study conducted by Alba et. Al, the efficacy of CJC-1295 was examined against mice with GHRH gene knockout (GHRHKO). While injections with a normal GHRH analog showed no improvement in the growth of the mice, treatment with CJC-1295 was effective in stimulating growth for the mice with GHRH gene knockout (https://journals.physiology.org/doi/full/10.1152/ajpendo.00201.2006?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org).

 

Three groups of 1-week old mice were treated with 2 microgram of CJC-1295 for 5 weeks. One group was injected every 24 hours, one group every 48 hours, and one group every 72 hours. The researchers measure total body weight, length, and the length of the tibia and femur. It was found that mice injected daily experienced the largest increase in body weight and length and maintained the average body composition and length. Mice receiving treatment every 48 hours or 72 hours showed an increase in femur and tibia length but did not reach full growth. Overall, lean mass and subcutaneous fat remained the same across all three experimental groups.

 

With treatment of CJC-1295 there was an increase in GH mRNA and total pituitary RNA. This suggests that the somatotroph cells have proliferated which was further confirmed through the use of immunohistochemistry images. Overall, the findings of this study indicate that in mice, daily supplementation with CJC-1295 allows the mice to maintain normal growth patterns, more so than injections every 48 hours or 72 hours.

 

What is DAC?

The Drug Affinity Complex (DAC) was created by ConjuChem in order to provide protection to the peptides and combat peptide breakdown due to the presence of the peptidase enzyme. In addition to combatting peptide breakdown, the addition of DAC helps to slow down kidney excretion. For both in vivo and ex vivo mechanisms, DAC covalently bonds with albumin in order to resist peptide breakdown. In addition to resisting peptidase cleavage, the covalent bonding of DAC allows for DAC to reach a wider distribution of the compounds throughout the body (https://www.conjuchem.com/technology/dac.html).

 

Benefits of Using CJC 1295 with DAC

There are many benefits to supplementing CJC-1295 with DAC. While supplementing CJC-1295 with DAC, the half life of the compound is greatly increased, indicating that there is more growth hormone circulating for a longer period of time. Additionally, the use of CJC-1295 has been shown to also lead to an increase in levels of insulin growth factor 1 which has been shown to have positive developmental and anabolic effects (https://canvas.wisc.edu/eportfolios/2985/Home/CJC1295_DAC_or_no_DAC).

 

Peptides Prefer the Cold

In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.

Swab the top of the vial with 95% alcohol wipe before accessing.

Only Mix with Sterile Bacteriostatic Water

Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.

Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.

 

Reconstituted peptide solution should be stored around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

 

Also known as DAC:GRF (short for drug affinity complex:growth hormone-releasing factor), is a synthetic analogue of growth hormone-releasing hormone (GHRH) (also known as growth hormone-releasing factor (GRF)) and a growth hormone secretagogue (GHS) which was developed by ConjuChem Biotechnologies.[1][2][3] It is a modified form of GHRH (1-29) with improved pharmacokinetics, especially in regard to half-life.[1][2][3][4]

CJC-1295 Peptide is under active investigation in a number of cell culture and animal models.
Our CJC-1295 Peptide is stored and handled according to industry guidelines to ensure stability.

Most peptides, especially shorter ones, can be preserved for weeks if careful.
Before drawing solution from any dissolved peptide vial, fill the pin with air to the same measurement you will be filling with solution, ie. if you plan to take 0.1 ml, first fill the pin with 0.1ml of air, push the air into the vial, and then draw the peptide back up to the 0.1 ml marker. Doing so will maintain even pressure in the vial. Always remember to remove air bubbles from the pin by flicking it gently, needle side up, and pushing bubbles out. In addition, push out a tiny amount of solution to ensure there is no air left in the metal tip.
The purity and sterility of bacteriostatic water are essential to prevent contamination and to preserve the shelf-life of dissolved peptides.
Push the pin through the rubber stopper at a slight angle, so that you inject the bacteriostatic water toward the inside wall of the vial, not directly onto the powder.
Lyophilized peptide should be stored at -20°C (freezer), and the reconstituted peptide solution at 4°C (refrigerated). Do not freeze once reconstituted.

NEVER SHAKE A VIAL TO MIX.

Air bubbles are unfavorable to the stability of proteins.
Storage: Lyophilized peptide should be stored at -20°C (freezer), and the reconstituted peptide solution at 4°C (refrigerated). Do not freeze once reconstituted.

**LAB USE ONLY**

*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

 

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CJC-1295 DAC for saleCJC-1295 DAC for saleCJC-1295 DAC for sale

 

Peptide Purity Chart

File Name View/Download
03-18-2022-CJC-1295-Certificate-of-Authenticity-COA.pdf

 

 

VIEW CERTIFICATES OF AUTHENTICITY (COA)

 

 

Additional information

Weight 1 oz
Dimensions 0.5 × 0.5 × 1 in
Molar Mass

3367.954 g·mol−1

Molecular Formula

C152H252N44O42

Size

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