Description

CJC-1295 (No DAC) PEPTIDE

 

 

 

CAS Number	446036-97-1
Other Names	CJC1295 Without DAC, CJC1295 No DAC, CJC 1295 DAC
IUPAC Name	4-[[1-[[1-[[1-[[1-[[5-amino-1-[[1-[[1-[[1-[[6-amino-1-[[1-[[1-[[1-[[5-amino-1-[[1-[[1-[[1-[[1-[[6-amino-1-[[1-[[1-[[5-amino-1-[[1-[[1-[[1-[[1-[(1-amino-5-carbamimidamido-1-oxopentan-2-yl)amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]-4-oxobutanoic acid
Molecular Formula	C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight	3367.9
Purity	≥99% Pure (LC-MS)
Liquid Availability	N/A
Powder Availability	2 milligrams, 5 milligrams (lyophilized/freeze-dried)
Storage Condition	Store cold, keep refrigerated. Do NOT freeze.
Terms	All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

**Important Information: Each peptide comes lyophilized/freeze-dried and must be reconstituted with Bacteriostatic Water in order to be dispensable in liquid form.

Watch How To Reconstitute Peptide Video Here

CJC-1295 is a peptide supplement that works to stimulate the release of growth hormone (GH) from the pituitary gland. CJC-1295 is considered unique due to the covalent addition of a maleimidopropionic acid group to the C-terminus of the peptide. The covalent attachment allows it to bind to proteins in the plasma such as serum albumin. Additionally, with the covalent conjugation of molecules, the peptide has a much longer half-life than it would without the bond.

 

Effects of CJC-1295 as a GRF-Analog

In a study conducted by Jetté et. Al, various types of hGRF 1-29-albumin biconjugates were examined to see which had the greatest effect on the release of growth hormone (GH) from the anterior pituitary glands in rats.

Researchers tested three different maleimido derivatives of human GH releasing factor, including CJC-1295, and from there they were synthesized and biconjugated to serum albumin. Following synthesization and conjugation, all three of the compounds were seen to have had improved stability against dipeptidylpeptidase-IV in vitro. From there each of the compounds was administered to male Sprague Dawley rats and secretion of plasma GH levels was tracked to watch for increases.

After measurements, it was found that CJC-1295 was the most effective of the three compounds in regards to increasing levels of GH. Results showed that by supplementing CJC-1295 to the rats that there was a 4-fold increase in plasma GH levels over a 2-hour period. CJC-1295 was selected for further pharmacokinetic investigation after research showed it was found in the plasma for as long as 72 hours after treatment. A Western blot analysis was performed on the rats following treatment with CJC-1295 and it was shown that there was a presence of a CJC-1295 immunoreactive species that appeared after 15 minutes and remained in circulation for more than 24 hours (https://pubmed.ncbi.nlm.nih.gov/15817669/).

 

What is DAC?

DAC stands for Drug Affinity Complex and was created by ConjuChem in order to address the issue of peptide protection and combat the issue of peptide degradation. Additionally, DAC helps to slow down rapid kidney excretion. DAC works to protect against peptide degradation by covalently bonding to serum albumin either in an in vivo or ex vivo fashion. By covalently bonding DAC to albumin, the compound is able to block peptidase cleavage. Additionally, the attachment to DAC allows for more widespread distribution of the compounds throughout the body (https://www.conjuchem.com/technology/dac.html).

 

Benefits of Using CJC 1295 without DAC

There are both drawbacks and benefits to supplementing CJC-1295 without DAC. While the addition of DAC allows for a longer half-life, using CJC-1295 without the addition of DAC allows for more natural bodily functioning as the release of GH is faster and more natural. Regardless of whether there is DAC or no DAC, there are similar, potent results associated with the use of CJC-1295 (https://canvas.wisc.edu/eportfolios/2985/Home/CJC1295_DAC_or_no_DAC).

Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

CJC-1295 (No DAC) is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

 

 

 

File Name	View/Download
09-09-2023-Umbrella-Labs-CJC-1295-No-DAC-Certificate-Of-Analysis-COA.pdf

 

VIEW CERTIFICATES OF ANALYSIS (COA)

 

Additional information

Weight	1 oz
Dimensions	0.5 × 0.5 × 1 in
Molar Mass	3367.954 g·mol−1
Molecular Formula	C152H252N44O42
Size	2 Milligrams, 5 Milligrams