CJC-1295 NO DAC PEPTIDE 2MG/5MG VIAL
$24.99 – $59.99
CJC-1295 is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.
- Additional information
CJC-1295 (No DAC) PEPTIDE
|Purity||≥99% Pure (LC-MS)|
|Storage||Store in a dry, cool, dark place. For best preservation, store at 4°C or colder away from bright light.|
|Terms||Lab Use Only. This information is for educational purposes only and does not constitute medical advice.|
CJC-1295 is a peptide supplement that works to stimulate the release of growth hormone (GH) from the pituitary gland. CJC-1295 is considered unique due to the covalent addition of a maleimidopropionic acid group to the C-terminus of the peptide. The covalent attachment allows it to bind to proteins in the plasma such as serum albumin. Additionally, with the covalent conjugation of molecules, the peptide has a much longer half-life than it would without the bond.
Effects of CJC-1295 as a GRF-Analog
In a study conducted by Jetté et. Al, various types of hGRF 1-29-albumin biconjugates were examined to see which had the greatest effect on the release of growth hormone (GH) from the anterior pituitary glands in rats.
Researchers tested three different maleimido derivatives of human GH releasing factor, including CJC-1295, and from there they were synthesized and biconjugated to serum albumin. Following synthesization and conjugation, all three of the compounds were seen to have had improved stability against dipeptidylpeptidase-IV in vitro. From there each of the compounds was administered to male Sprague Dawley rats and secretion of plasma GH levels was tracked to watch for increases.
After measurements, it was found that CJC-1295 was the most effective of the three compounds in regards to increasing levels of GH. Results showed that by supplementing CJC-1295 to the rats that there was a 4-fold increase in plasma GH levels over a 2-hour period. CJC-1295 was selected for further pharmacokinetic investigation after research showed it was found in the plasma for as long as 72 hours after treatment. A Western blot analysis was performed on the rats following treatment with CJC-1295 and it was shown that there was a presence of a CJC-1295 immunoreactive species that appeared after 15 minutes and remained in circulation for more than 24 hours (https://pubmed.ncbi.nlm.nih.gov/15817669/).
What is DAC?
DAC stands for Drug Affinity Complex and was created by ConjuChem in order to address the issue of peptide protection and combat the issue of peptide degradation. Additionally, DAC helps to slow down rapid kidney excretion. DAC works to protect against peptide degradation by covalently bonding to serum albumin either in an in vivo or ex vivo fashion. By covalently bonding DAC to albumin, the compound is able to block peptidase cleavage. Additionally, the attachment to DAC allows for more widespread distribution of the compounds throughout the body (https://www.conjuchem.com/technology/dac.html).
Benefits of Using CJC 1295 without DAC
There are both drawbacks and benefits to supplementing CJC-1295 without DAC. While the addition of DAC allows for a longer half-life, using CJC-1295 without the addition of DAC allows for more natural bodily functioning as the release of GH is faster and more natural. Regardless of whether there is DAC or no DAC, there are similar, potent results associated with the use of CJC-1295 (https://canvas.wisc.edu/eportfolios/2985/Home/CJC1295_DAC_or_no_DAC).
Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.
CJC-1295, also known as DAC:GRF (short for drug affinity complex:growth hormone-releasing factor), is a synthetic analogue of growth hormone-releasing hormone (GHRH) (also known as growth hormone-releasing factor (GRF)) and a growth hormone secretagogue (GHS) which was developed by ConjuChem Biotechnologies. It is a modified form of GHRH (1-29) with improved pharmacokinetics, especially in regard to half-life.
NEVER SHAKE A VIAL TO MIX.
**LAB USE ONLY**
*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).