Description

DSIP (Delta Sleep-Inducing Peptide)

 

 

 

CAS Number	70754-23-3
Other Names	Delta Sleep-Inducing Peptide Phosphate, Dsip-P, P-DSIP
IUPAC Name	(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]acetyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-phosphonooxypropanoyl]amino]acetyl]amino]pentanedioic acid
Molecular Formula	C₃₅H₄₈N₁₀O₁₅
Molecular Weight	848.8
Purity	≥99% Pure (LC-MS)
Liquid Availability	N/A
Powder Availability	2 milligrams, 5 milligrams (lyophilized/freeze-dried)
Storage Condition	Store cold, keep refrigerated. Do NOT freeze.
Terms	All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

**Important Information: Each peptide comes lyophilized/freeze-dried and must be reconstituted with Bacteriostatic Water in order to be dispensable in liquid form.

Watch How To Reconstitute Peptide Video Here

Delta Sleep Inducing Peptide (DSIP) is a nonapeptide that was initially isolated from the cerebral venous blood of rabbits and hypothesized to act as a sleep aid. A study conducted by Stanojlovic et. Al examined the relationship between sleep and epilepsy and whether or not DSIP can play a role in regulating metaphit-induced audiogenic epilepsy.

Metaphit is a synthetically produced substance that was shown to stimulate the subject by increasing brain excitement, and has also been shown to cause seizures in rats. In this study it was administered to 2-month-old male Wistar rats. From there, the rats were exposed to audiogenic stimulation in order to test for any seizure activity or convulsions.

The rats were split into 1 control group and 3 experimental groups. The first experimental group was treated with only 10 mg/kg of metaphit. The second experimental group was treated with metaphit and 1 mg/kg of DSIP. The final experimental group was treated with only 1 mg/kg of DSIP by itself.

The study confirmed that metaphit induced high-voltage activity, and synchronized spike on the EEG only 30 minutes after administration. In the experimental group that received metaphit and DSIP, DSIP was shown to decrease the mean seizure grade as well as the overall duration of the seizure. This indicates that due to its ability to move through the blood-brain barrier, DSIP could be beneficially used against sleep disorders due to the similarity between epilepsy and disturbed sleep (https://pubmed.ncbi.nlm.nih.gov/11797457/).

 

Effects of DSIP on ATP Production

DSIP has been linked to different stress-related metabolic disturbances. As previous studies show, mitochondria are sensitive to stressful conditions, so researchers Khvatova et.Al examined how the administration of DSIP can affect oxidative phosphorylation and ATP production in the brain mitochondria of rats. The initial findings of this study emphasized the increased rate of phosphorylated respiration V3 and ADP phosphorylation as well as the increase of the respiratory control ratio.

The researchers continued on to study the effects of DSIP under hypoxic conditions that alter the respiratory activity in the mitochondria. In rats that were subjected to hypoxic conditions, there was a drastic decrease in V3 and ADP/t levels. However, when the rats were IV injected 120 microg/kg of DSIP prior to being put in hypoxic conditions it was found that the stress-induced decrease in mitochondrial respiratory activity was completely eliminated. Overall this study comes to the conclusion that DSIP could potentially be beneficial in enhancing the efficiency of the oxidative phosphorylation process which could lead to a better understanding of antioxidant and stress-protective behaviors (https://www.sciencedirect.com/science/article/abs/pii/S0196978103000408).

 

Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

DSIP is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

File Name	View/Download
08-20-2023-Umbrella-Labs-DSIP-Certificate-Of-Analysis-COA.pdf

 

 

 

VIEW CERTIFICATES OF ANALYSIS (COA)

 

Additional information

Weight	1 oz
Dimensions	0.5 × 0.5 × 1 in
Size	2 Milligrams, 5 Milligrams