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Epitalon Peptide

Epitalon is a simple peptide comprised of four common amino acids in this sequence: Ala-Glu-Asp-Gly

View Peptide Purity Reference Chart

*The information herein is for educational and informational purposes only. THIS PRODUCT IS FOR RESEARCH USE ONLY. For use in animal studies, all research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).


Storage: Lyophilized peptide should be stored at -20°C (freezer), and the reconstituted peptide solution at 4°C (refrigerated). Do not freeze once reconstituted.

[1] C. Bartsch, The pineal gland and cancer : neuroimmunoendocrine mechanisms in malignancy. Springer, 2001.

[2] V. K. Khavinson, A. T. Kopylov, B. V. Vaskovsky, G. A. Ryzhak, and N. S. Lin’kova, “Identification of Peptide AEDG in the Polypeptide Complex of the Pineal Gland,” Bull. Exp. Biol. Med., vol. 164, no. 1, pp. 41–43, Nov. 2017.

[3] V. K. Khavinson, “Peptides and Ageing.,” Neuro Endocrinol. Lett., vol. 23 Suppl 3, pp. 11–144, 2002.

[4] I. A. Vinogradova, A. V. Bukalev, M. A. Zabezhinski, A. V. Semenchenko, V. K. Khavinson, and V. N. Anisimov, “Geroprotective effect of Ala-Glu-Asp-Gly peptide in male rats exposed to different illumination regimens,” Bull. Exp. Biol. Med., vol. 145, no. 4, pp. 472–477, Apr. 2008.

[5] I. A. Vinogradova, A. V. Bukalev, M. A. Zabezhinski, A. V. Semenchenko, V. K. Khavinson, and V. N. Anisimov, “Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes,” Bull. Exp. Biol. Med., vol. 144, no. 6, pp. 825–830, Dec. 2007.

[6] V. N. Anisimov et al., “Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice,” Biogerontology, vol. 4, no. 4, pp. 193–202, 2003.

[7] L. S. Kozina, A. V. Arutjunyan, and V. K. Khavinson, “Antioxidant properties of geroprotective peptides of the pineal gland,” Arch. Gerontol. Geriatr., vol. 44, pp. 213–216, Jan. 2007.

[8] G. Kossoy et al., “Epitalon and colon carcinogenesis in rats: Proliferative activity and apoptosis in colon tumors and mucosa,” Int. J. Mol. Med., vol. 12, no. 4, pp. 473–477, Oct. 2003.

[9] V. N. Anisimov et al., “Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice,” Int. J. Cancer, vol. 101, no. 1, pp. 7–10, Sep. 2002.

[10] G. Kossoy, V. N. Anisimov, H. Ben-Hur, N. Kossoy, and I. Zusman, “Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.,” In Vivo, vol. 20, no. 2, pp. 253–7.

[11] V. Khavinson, M. Razumovsky, S. Trofimova, R. Grigorian, and A. Razumovskaya, “Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.,” Neuro Endocrinol. Lett., vol. 23, no. 4, pp. 365–8, Aug. 2002.

[12] V. Khavinson, N. Goncharova, and B. Lapin, “Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys.,” Neuro Endocrinol. Lett., vol. 22, no. 4, pp. 251–4, Aug. 2001.

[13] R. G. Goya, G. M. Cónsole, C. B. Hereñú, O. A. Brown, and O. J. Rimoldi, “Thymus and Aging: Potential of Gene Therapy for Restoration of Endocrine Thymic Function in Thymus-Deficient Animal Models,” Gerontology, vol. 48, no. 5, pp. 325–328, 2002.

[14] N. D. Goncharova, A. A. Vengerin, V. K. Khavinson, and B. A. Lapin, “Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas,” Exp. Gerontol., vol. 40, no. 1–2, pp. 51–57, Jan. 2005.

[15] O. V. Korkushko, V. K. Khavinson, V. B. Shatilo, and I. A. Antonyk-Sheglova, “Peptide Geroprotector from the Pituitary Gland Inhibits Rapid Aging of Elderly People: Results of 15-Year Follow-Up,” Bull. Exp. Biol. Med., vol. 151, no. 3, pp. 366–369, Jul. 2011.

Additional information

Weight 1 oz
Dimensions 0.5 × 0.5 × 1 in
CAS Number‎

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