Fragment 176-191 is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

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Fragment 176-191


fragment peptide fragment peptide fragment peptide fragment peptide fragment peptide fragment peptide fragment peptide fragment peptide


fragment peptide


Molecular Formula C₇₈H₁₂₅N₂₃O₂₃S₂
Molecular Weight 1812.12
Purity ≥99% Pure (LC-MS)
Storage Store in a dry, cool, dark place. For best preservation, store at 4°C or colder away from bright light.
Terms Lab Use Only. This information is for educational purposes only and does not constitute medical advice.


Fragment 176-191 is a peptide that is a molecular fragment of Human Growth Hormone (HGH) consisting of 16 amino acids attached to the C-terminus of positions 176 and 191. It is most commonly known for its lipolytic activity and ability to suppress the development of new body fat. 


Effect of Fragment 176-191 on Fat Loss

Fragment 176-191 is commonly referred to as a lipolytic fragment due to the dramatic weight loss effects it has exhibited in animal-based studies. The fat-burning and weight loss properties are seemingly driven by the increased production of beta-3-adrenergic receptors (ADRB3) that are commonly linked to fat burning in adipose tissue and thermogenesis in skeletal muscles. 


A notable study examined how fragment 176-191 affected weight loss and fat burning in mice with the ADRB3 knockout gene. Both lean and obese mice were administered varying doses of fragment 176-191 over a three-week period of time. Interestingly enough, the weight loss effects of the peptide were seen only in obese mice which experience a 50% decrease in body fat. The lean mice included in the study maintained normal body weight and body fat percentage regardless of whether or not they were treated with fragment 176-191. 


The results of this study indicate that fragment 176-191 directly acts on burning adipose tissue which leads to the overall weight loss benefits. Additionally, this study suggests that there could potentially be secondary regulatory pathways that drive lipolysis, capable of overriding the functioning of ADRB3 primarily in lean mice near an ideal body weight. Future research and supplemental studies could be conducted regarding these secondary regulatory pathways and the role they play in energy homeostasis ( 


Effects of Fragment 176-191 on Plasma Glucose and Insulin Levels

In addition to its weight loss and fat-burning capabilities, fragment 176-191 has also shown promise in increasing insulin levels and lowering blood sugar. Various animal-based studies examining the hypoglycemic effects of Human Growth Hormone (hGH)  have shown that the C-terminus of the peptide is responsible for its ability to lower blood sugar. That being said, fragment 176-191 is the hGH derivative that most efficiently and effectively lowers blood sugar levels. In addition to lowering levels of blood sugar, administration of the fragment is also able to increase levels of insulin. 


Further studies tested the efficacy of fragment 176-191 in vivo in normal rats. Results of the study highlighted that administration of the fragment led to a short-lived spike in glucose levels as well as a sustained increase in plasma insulin levels as well. With the combination of increased insulin levels and decreased blood glucose levels, further research on this peptide will be conducted regarding the efficacy of treating prediabetes and type 2 diabetes with fragment 176-191 (  


Peptides Prefer the Cold

In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.

Swab the top of the vial with a 95% alcohol wipe before accessing.

Only Mix with Sterile Bacteriostatic Water

Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.

Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.

Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

Fragment 176-191

The fragment 176-191 is a fragment of the Human Growth Hormone amino acid sequence which is being invesstigated for its lipolytic effects.

Fragment 176-191 Peptide is under active investigation in a number of cell culture and animal models.
Our fragment 176-191 Peptide is stored and handled according to industry guidelines to ensure stability.


Keep peptide vials refrigerated at all times to reduce peptide bond breakdown. DO NOT FREEZE. Most peptides, especially shorter ones, can be preserved for weeks if careful.
Always swab the top of the vial with an alcohol wipe, rubbing alcohol or 95% ethanol before use.
Before drawing solution from any dissolved peptide vial, fill the pin with air to the same measurement you will be filling with solution, ie. if you plan to take 0.1 ml, first fill the pin with 0.1ml of air, push the air into the vial, and then draw the peptide back up to the 0.1 ml marker. Doing so will maintain even pressure in the vial. Always remember to remove air bubbles from the pin by flicking it gently, needle side up, and pushing bubbles out. In addition, push out a tiny amount of solution to ensure there is no air left in the metal tip.


The purity and sterility of bacteriostatic water are essential to prevent contamination and to preserve the shelf-life of dissolved peptides.
Push the pin through the rubber stopper at a slight angle, so that you inject the bacteriostatic water toward the inside wall of the vial, not directly onto the powder.
Lyophilized peptide should be stored at -20°C (freezer), and the reconstituted peptide solution at 4°C (refrigerated). Do not freeze once reconstituted.


Air bubbles are unfavorable to the stability of proteins.


*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).



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Fragment 176-191 for saleFragment 176-191 for sale Fragment 176-191 for sale

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Peptide Purity Chart


Pure Peptide FRAB 176-191 Certificate of Authenticity COA

File Name View/Download
06-04-2021-FRAG-176-191-Certificate-of-Authenticity-COA.pdf fragment peptide






Additional information

Weight 1 oz
Dimensions 0.5 × 0.5 × 1 in