Description

Fragment 176-191

 

 

CAS Number	66004-57-7
Other Names	Somatotropin (176-191), DTXSID10216216, L-Phenylalanine, L-phenylalanyl-L-leucyl-L-arginyl-L-isoleucyl-L-valyl-L-glutaminyl-L-cysteinyl-L-arginyl-L-seryl-L-valyl-L-alpha-glutamylglycyl-L-seryl-L-cysteinylglycyl-, cyclic (7-14)-disulfide
IUPAC Name	[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl] (4S)-5-[[2-[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-sulfanylpropanoyl]amino]acetyl]amino]-3-phenylpropanoyl]oxy-2-oxoethyl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-5-carbamimidamido-2-[[(2R)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]-3-sulfanylidenepropanoyl]amino]pentanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoate
Molecular Formula	C₇₈H₁₂₅N₂₃O₂₃S₂
Molecular Weight	1812.12
Purity	≥99% Pure (LC-MS)
Liquid Availability	N/A
Powder Availability	2 milligrams, 5 milligrams, 10 milligrams (lyophilized/freeze-dried)
Storage	Store in a dry, cool, dark place. For best preservation, store at 4°C or colder away from bright light.
Terms	All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

**Important Information: Each peptide comes lyophilized/freeze-dried and must be reconstituted with Bacteriostatic Water in order to be dispensable in liquid form.

 

Fragment 176-191 is a peptide that is a molecular fragment of Human Growth Hormone (HGH) consisting of 16 amino acids attached to the C-terminus of positions 176 and 191. It is most commonly known for its lipolytic activity and ability to suppress the development of new body fat.

 

Effect of Fragment 176-191 on Fat Loss

Fragment 176-191 is commonly referred to as a lipolytic fragment due to the dramatic weight loss effects it has exhibited in animal-based studies. The fat-burning and weight loss properties are seemingly driven by the increased production of beta-3-adrenergic receptors (ADRB3) that are commonly linked to fat burning in adipose tissue and thermogenesis in skeletal muscles.

A notable study examined how fragment 176-191 affected weight loss and fat burning in mice with the ADRB3 knockout gene. Both lean and obese mice were administered varying doses of fragment 176-191 over a three-week period of time. Interestingly enough, the weight loss effects of the peptide were seen only in obese mice which experience a 50% decrease in body fat. The lean mice included in the study maintained normal body weight and body fat percentage regardless of whether or not they were treated with fragment 176-191.

The results of this study indicate that fragment 176-191 directly acts on burning adipose tissue which leads to the overall weight loss benefits. Additionally, this study suggests that there could potentially be secondary regulatory pathways that drive lipolysis, capable of overriding the functioning of ADRB3 primarily in lean mice near an ideal body weight. Future research and supplemental studies could be conducted regarding these secondary regulatory pathways and the role they play in energy homeostasis (https://www.canpeptides.com/blog/hgh-fragment-176-191-research.html).

 

Effects of Fragment 176-191 on Plasma Glucose and Insulin Levels

In addition to its weight loss and fat-burning capabilities, fragment 176-191 has also shown promise in increasing insulin levels and lowering blood sugar. Various animal-based studies examining the hypoglycemic effects of Human Growth Hormone (hGH) have shown that the C-terminus of the peptide is responsible for its ability to lower blood sugar. That being said, fragment 176-191 is the hGH derivative that most efficiently and effectively lowers blood sugar levels. In addition to lowering levels of blood sugar, administration of the fragment is also able to increase levels of insulin.

Further studies tested the efficacy of fragment 176-191 in vivo in normal rats. Results of the study highlighted that administration of the fragment led to a short-lived spike in glucose levels as well as a sustained increase in plasma insulin levels as well. With the combination of increased insulin levels and decreased blood glucose levels, further research on this peptide will be conducted regarding the efficacy of treating prediabetes and type 2 diabetes with fragment 176-191 (https://www.canpeptides.com/blog/hgh-fragment-176-191-research.html).

Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with a 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

Fragment 176-191 is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

 

 

File Name	View/Download
06-05-2023-Umbrella-Labs-Frag-176-191-Certificate-Of-Authenticity-COA.pdf

 

 

VIEW CERTIFICATES OF AUTHENTICITY (COA)

 

Additional information

Weight	1 oz
Dimensions	0.5 × 0.5 × 1 in
Size	2 Milligrams, 5 Milligrams, 10 Milligrams