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GHK-Cu Copper Peptide

GHK-Cu is a simple tri-peptide copper complex with the following sequence: Gly-His-Lys

CAS: 89030-95-5

View Peptide Purity Reference Chart

*The information herein is for educational and informational purposes only. THIS PRODUCT IS FOR RESEARCH USE ONLY. For use in animal studies, all research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

Storage: Lyophilized peptide should be stored at -20°C (freezer), and the reconstituted peptide solution at 4°C (refrigerated). Do not freeze once reconstituted.


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[3] X.-M. Zhou et al., “GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGFβ1/Smad-Mediated Epithelial-to-Mesenchymal Transition,” Front. Pharmacol., vol. 8, p. 904, Dec. 2017.

[4] L. Pickart, J. M. Vasquez-Soltero, and A. Margolina, “GHK and DNA: Resetting the Human Genome to Health,” Biomed Res. Int., vol. 2014, pp. 1–10, 2014.

[5] J. J. Hostynek, F. Dreher, and H. I. Maibach, “Human skin retention and penetration of a copper tripeptide in vitro as function of skin layer towards anti-inflammatory therapy,” Inflamm. Res., vol. 59, no. 11, pp. 983–988, Nov. 2010.

[6] L. Pickart, J. M. Vasquez-Soltero, and A. Margolina, “The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health.,” Oxid. Med. Cell. Longev., vol. 2012, p. 324832, 2012.

[7] G. Hou and X. Zhou, “Antioxidant and anti-inflammation effect of GHK-Cu in bleomycin-induced pulmonary fibrosis,” in ILD/DPLD of known origin, 2018, vol. 52, no. suppl 62, p. PA2957.

[8] F. X. Maquart et al., “In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds.,” J. Clin. Invest., vol. 92, no. 5, pp. 2368–76, Nov. 1993.

[9] V. Arul, D. Gopinath, K. Gomathi, and R. Jayakumar, “Biotinylated GHK peptide incorporated collagenous matrix: A novel biomaterial for dermal wound healing in rats,” J. Biomed. Mater. Res. Part B Appl. Biomater., vol. 73B, no. 2, pp. 383–391, May 2005.

[10] X. Wang et al., “GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis,” Wound Repair Regen., vol. 25, no. 2, pp. 270–278, Apr. 2017.

[11] J. D. Pollard, S. Quan, T. Kang, and R. J. Koch, “Effects of Copper Tripeptide on the Growth and Expression of Growth Factors by Normal and Irradiated Fibroblasts,” Arch. Facial Plast. Surg., vol. 7, no. 1, p. 27, Jan. 2005.

[12] T. F. Lane, M. L. Iruela-Arispe, R. S. Johnson, and E. H. Sage, “SPARC is a source of copper-binding peptides that stimulate angiogenesis,” J. Cell Biol., vol. 125, no. 4, pp. 929–943, May 1994.

[13] H.-R. Choi et al., “Stem cell recovering effect of copper-free GHK in skin,” J. Pept. Sci., vol. 18, no. 11, pp. 685–690, Nov. 2012.

[14] L. Pickart and A. Margolina, “The Effect of the Human Plasma Molecule GHK-Cu on Stem Cell Actions and Expression of Relevant Genes,” OBM Geriatr., vol. 2, no. 3, pp. 1–1, Aug. 2018.

[15] S. Jose, M. L. Hughbanks, B. Y. K. Binder, G. C. Ingavle, and J. K. Leach, “Enhanced trophic factor secretion by mesenchymal stem/stromal cells with Glycine-Histidine-Lysine (GHK)-modified alginate hydrogels,” Acta Biomater., vol. 10, no. 5, pp. 1955–1964, May 2014.

[16] G. Lindner, G. Grosse, W. Halle, and P. Henklein, “[The effect of a synthetic tripeptide nervous tissue cultured in vitro],” Z. Mikrosk. Anat. Forsch., vol. 93, no. 5, pp. 820–828, 1979.

[17] H. Zhang, Y. Wang, and Z. He, “Glycine-Histidine-Lysine (GHK) Alleviates Neuronal Apoptosis Due to Intracerebral Hemorrhage via the miR-339-5p/VEGFA Pathway,” Front. Neurosci., vol. 12, p. 644, Sep. 2018.

Additional information

Weight 1 oz
Dimensions 0.5 × 0.5 × 1 in
CAS Number‎

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