Description

GHK-Cu Copper Peptide

 

 

CAS Number	130120-57-9
Other Names	Prezatide copper acetate, BCP16167, GHK-Cu(Prezatide Copper Acetate), BCP16167
IUPAC Name	copper;acetic acid;6-amino-2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid
Molecular Formula	C₁₆H₂₈CuN₆O₆⁺²
Molecular Weight	463.98
Purity	≥99% Pure (LC-MS)
Liquid Availability	N/A
Powder Availability	5 milligrams, 10 milligrams, 50 milligrams (lyophilized/freeze-dried)
Storage Condition	Store cold, keep refrigerated. Do NOT freeze.
Terms	All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

**Important Information: Each peptide comes lyophilized/freeze-dried and must be reconstituted with Bacteriostatic Water in order to be dispensable in liquid form.

Watch How To Reconstitute Peptide Video Here

GHK (glycyl-L-histidyl-L-lysine) forms a complex with copper in order to form GHK-Cu. GHK-Cu is a peptide that has been shown to play a role in skin repair and wound healing. By supplementing GHK-Cu, there is an increased synthesis of collagen, decorin, chondroitin sulfate, and dermatan sulfate. GHK-Cu was shown to attract immune system cells and endothelial cells to injury sites. Furthermore, a study conducted by Pickert et. Al found that GHK-Cu increases the rate of wound healing decreases rejection of transplanted skin grafts, and even has anti-inflammatory properties.

Pickert et. Al additionally cited various other animal-based studies that indicated GHK-Cu plays a role in wound healing in many forms. GHK-Cu most notably played a role in the acceleration of wound healing and formation of new blood vessels as well as the increase in antioxidant levels in rabbits. Further cited studies found that in dogs, GHK-Cu was shown to repair damage to the GI tract, skin, hair follicles, bone tissues, and even their foot pads. In rats, mice, and pigs, treatment with GHK-Cu assisted in increasing the rate of systemic wound healing. GHK-Cu was also shown to play a role in ischemic and diabetic wound healing in rats, as well as decreasing TNF-alpha levels and increasing collagen synthesis (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508379/)

 

Anti-Inflammatory Effects of GHK-Cu

As it was mentioned above, GHK-Cu is shown to have antioxidant and anti-inflammatory properties. This is due to the fact that GHK is able to inactivate the damaging byproducts released from free radical reactions. GHK was also shown to combat copper-dependent oxidation of low-density lipoproteins, while various other common antioxidants, such as superoxide dismutase, only provided protection against oxidation up to 20%.

 

CHK-Cu Respiratory Implications

Due to the anti-inflammatory properties of GHK-Cu, researchers tested how the compound would affect acute lung injury and lung damaged due to COPD. It was found that overall GHK-Cu was able to aid in the remodeling and regeneration of connective tissue. Additionally, GHK demonstrated the ability to reverse the expression of various genes, most notably, the gene signature of COPD. In addition to reversing the expression of the COPD gene, it was found that GHK is capable of activating the opposite pathway, TNF-beta.

Researchers also found that when treating mice with GHK-Cu, they were able to protect the lungs from acute injury and were able to stop the filtration of inflammatory cells into the lungs. The study also showed that GHK-Cu was able to decrease the production of IL-6 and TNF-1 while increasing the activity of superoxide dismutase by blocking the activation of NFκB’s p65 and p38 MAPK. The p38 MAPK pathway allows response to external stimuli and can affect levels of apoptosis as well as gene expression and skin differentiation, while the activation of NFκB p65 has shown a correlation to the development of various types of cancer as well as diseases related to aging such as cardiovascular disease, osteoporosis, and Alzheimer’s (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/).

Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with a 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

GHK-Cu is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

 

 

*Note: A slight coloration shade may occur in between different batches; this is a normal occurrence for this research compound.

 

 

 

File Name	View/Download
01-05-2023-Umbrella-Labs-GHK-Cu-5mg-Certificate-Of-Analysis-COA.pdf

 

 

VIEW CERTIFICATES OF ANALYSIS (COA)

 

Additional information

Weight	1 oz
Dimensions	0.5 × 0.5 × 1 in
Size	5 Milligrams, 10 Milligrams, 50 Milligrams