Description

MGF (Mechano Growth Factor)

 

 

 

CAS Number	77591-33-4
Other Names	TRIFLUOROMAGNESATE, MGF, Mechano Growth Factor
IUPAC Name	N/A
Molecular Formula	C₁₂₁H₂₀₀N₄₂O₃₉
Molecular Weight	2888.16
Purity	≥99% Pure (LC-MS)
Liquid Availability	N/A
Powder Availability	2 milligrams (lyophilized/freeze-dried)
Storage Condition	Store cold, keep refrigerated. Do NOT freeze.
Terms	All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

 

**Important Information: Each peptide comes lyophilized/freeze-dried and must be reconstituted with Bacteriostatic Water in order to be dispensable in liquid form.

Watch How To Reconstitute Peptide Video Here

What is Mechano Growth Factor

Mechano Growth Factor (MGF) is a peptide commonly found in skeletal muscle and helps respond to muscle stress and injury by regulating cell proliferation. MGF is considered to be a variant splice of insulin-growth factor 1 (IGF-1). IGF-1 is unique as it is composed out of 6 exons and 5 mRNA codings for different isoforms. These isoforms, IGF-1Ea, IGF-1Eb, and IGF-1Ec, were found through mRNA splicing. IGF-1Ea is the isoform normally found in the liver, while IGF-1Eb and IGF-1Ec are found in the muscle. Animal studies have found that when muscle tissue is damaged by stress or injury, the expression of IGF-1Eb is upregulated. Since the damage to the muscle was caused in a “mechano-sensitive manner”, the isoform was given the common name, Mechano Growth Factor.

Effects of MGF on Cellular Regeneration

As it was previously mentioned, MGF is the common name for the IGF-1Eb isoform that is capable of promoting healing in damaged muscle tissue. Researchers Matheny et. Al examined the beneficial effects MGF has on satellite cell activity, neuroprotection, and aging.

The researchers cited various studies examining the correlation between MGF and the activation of satellite cells. The first cited study took place in 2003 and observed how the satellite cells of the tibialis anterior (TA) muscle in rats responded to MGF administration following damage caused by stretching, electrical stimulation, or myotoxin injection. Results found that levels of IGF-1Eb (MGF) dramatically increased following the damage. However, it was shown that levels spiked before the satellite cells became active which led researchers to conclude that the protein byproducts of increased MGF had a positive effect on satellite cell activation. Further studies built upon this information, concluding that MGF led to an increase in “desmin-positive myogenic precursor cells”, allowing the researchers to conclude that MGF has beneficial effects on cell proliferation in skeletal muscles.

Neuroprotective Benefits of MGF

Additional research was conducted regarding the neuroprotective benefits of MGF. The first cited study from 2004 examined how MGF protected the facial nerves of rabbits. The subjects were all injected with MGF in their facial nerves and then underwent nerve avulsion. Results showed that following the procedure the rabbits were almost 100% protected from motor neuron loss. Further studies reported that injection of synthetic MGF combined with SH-SY5Y neurons protected against apoptosis and mitochondrial stress following the administration of a neurotoxin.

Furthermore, the study conducted by Matheny et. Al continued to examine the relationship between MGF levels and aging. When testing young, middle-aged, and old rats there was initially no change in levels of MGF in the skeletal muscles. However, all ages of mice underwent a surgical ablation to the distal gastrocnemius tendon. 5 days after the ablation all mice showed improved levels of MGF. Additionally, the study found that MGF increased the most in young rats while older rats did not reach the same level of induction, indicating that improvement of MGF levels is age dependent. However, other popular studies found that there is no age-related component and when rats were subject to the same amount of stress and damage, MGF levels increased at a similar rate (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840678/).

Peptides Prefer the Cold

In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with a 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

MGF is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

 

 

File Name	View/Download
03-28-2022-MGF-2MG-Certificate-Of-Analysis-COA.pdf

 

 

VIEW CERTIFICATES OF ANALYSIS (COA)

 

 

Additional information

Weight	1 oz
Dimensions	0.5 × 0.5 × 1 in