Description

Oxytocin

 

 

 

Molecular Formula	C₄₃H₆₆N₁₂O₁₂S₂
Molecular Weight	1007.2
Purity	≥99% Pure (LC-MS)
Storage	Store in a dry, cool, dark place. For best preservation, store at 4°C or colder away from bright light.
Terms	All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

 

Effects of Oxytocin on Depression

Oxytocin, also referred to as the love hormone, is one of the more commonly known peptides. Oxytocin naturally occurs in the hypothalamus and is released through the pituitary gland.
Additionally, the main role of oxytocin is to facilitate childbirth and lactating by promoting contraction of the uterus, as well as let-down of milk supply.

Furthermore, when oxytocin is released in various situations such as cuddling an animal or hugging a loved one, serotonin is released in the brain. Researchers Uvnäs-Moberg et. Al explored the link between oxytocin and depression in male Sprague-Dawley rats. The study examined how 20 mg/kg IP of the SSRI, citalopram, affects levels of plasma oxytocin.

Citalopram was administered on a daily basis over the course of 14 days and was measured through the use of the radioimmunoassay technique. The study found that the initial administration of citalopram was found to greatly increase levels of plasma oxytocin. After administering citalopram for 14 days it was found that levels of plasma oxytocin continued to increase upon administration of the SSRI. Overall the study concluded that the administration of SSRIs was able to release oxytocin and that oxytocin release should be studied in regard to the development of SSRIs and treatment of depression (https://link.springer.com/article/10.1007/s002130050867).

 

Effect of Oxytocin in Various Brain Regions

In a study conducted by Grinevich et. Al, the use of intracerebral microdialysis helped researchers to examine the location of oxytocin release in various animals such as rats, mice, and sheep. The main brain regions that were tested were limbic target regions, such as the dorsolateral and ventral septal areas, the dorsal hippocampus, and the central amygdala in rats, as well as the nucleus accumbens of voles, and the olfactory bulb, substantia nigra, and bed nucleus in sheep.

Stimulation of the paraventricular nucleus (PVN) was understood to have led to the release of oxytocin. The majority of the studies conducted attempting to determine where oxytocin was released within the brain were done on rats. That being said, it was difficult to truly determine the complete effects of PVN stimulation as technology is not developed enough to examine parvocellular nuclei. The reported effects of PVN stimulation were inferred primarily through data from magnocellular nuclei.

Results of this study showed that any sort of reproductive stimulation such as suckling, or mating increased the release of oxytocin in a region-dependent matter. In addition to reproductive stimulation, there were various emotional and physical stimuli that led to an increase in oxytocin release. “Forced swimming” led to oxytocin release in the PVN, SON, and amygdala, the presence of an aggressive male led to oxytocin release in the SON and septum in other males, and aggressive lactation attempts on a non-lactating female rat led to oxytocin release in PVN. These results indicate that different types of stimulation cause the region-dependent nature of oxytocin release (https://www.nature.com/articles/s41380-020-0802-9).

 

Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

Oxytocin is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

 

File Name	View/Download
09-08-2021-Oxytocin-Certificate-of-Authenticity-COA.pdf

 

 

VIEW CERTIFICATES OF AUTHENTICITY (COA)

 

 

Additional information

Weight	1 oz
Dimensions	0.5 × 0.5 × 1 in