OXYTOCIN PEPTIDE LIQUID SPRAY 15ML BOTTLE
Oxytocin is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.
- Additional information
|Purity||≥99% Pure (LC-MS)|
|Storage||Store in a dry, cool, dark place. For best preservation, store at 4°C or colder away from bright light.|
|Terms||Lab Use Only. This information is for educational purposes only and does not constitute medical advice.|
Effects of Oxytocin on Depression
Oxytocin, also referred to as the love hormone, is one of the more commonly known peptides. Oxytocin naturally occurs in the hypothalamus and is released through the pituitary gland.
Additionally, the main role of oxytocin is to facilitate childbirth and lactating by promoting contraction of the uterus, as well as let-down of milk supply.
Furthermore, when oxytocin is released in various situations such as cuddling an animal or hugging a loved one, serotonin is released in the brain. Researchers Uvnäs-Moberg et. Al explored the link between oxytocin and depression in male Sprague-Dawley rats. The study examined how 20 mg/kg IP of the SSRI, citalopram, affects levels of plasma oxytocin.
Citalopram was administered on a daily basis over the course of 14 days and was measured through the use of the radioimmunoassay technique. The study found that the initial administration of citalopram was found to greatly increase levels of plasma oxytocin. After administering citalopram for 14 days it was found that levels of plasma oxytocin continued to increase upon administration of the SSRI. Overall the study concluded that the administration of SSRIs was able to release oxytocin and that oxytocin release should be studied in regard to the development of SSRIs and treatment of depression (https://link.springer.com/article/10.1007/s002130050867).
Effect of Oxytocin in Various Brain Regions
In a study conducted by Grinevich et. Al, the use of intracerebral microdialysis helped researchers to examine the location of oxytocin release in various animals such as rats, mice, and sheep. The main brain regions that were tested were limbic target regions, such as the dorsolateral and ventral septal areas, the dorsal hippocampus, and the central amygdala in rats, as well as the nucleus accumbens of voles, and the olfactory bulb, substantia nigra, and bed nucleus in sheep.
Stimulation of the paraventricular nucleus (PVN) was understood to have led to the release of oxytocin. The majority of the studies conducted attempting to determine where oxytocin was released within the brain were done on rats. That being said, it was difficult to truly determine the complete effects of PVN stimulation as technology is not developed enough to examine parvocellular nuclei. The reported effects of PVN stimulation were inferred primarily through data from magnocellular nuclei.
Results of this study showed that any sort of reproductive stimulation such as suckling, or mating increased the release of oxytocin in a region-dependent matter. In addition to reproductive stimulation, there were various emotional and physical stimuli that led to an increase in oxytocin release. “Forced swimming” led to oxytocin release in the PVN, SON, and amygdala, the presence of an aggressive male led to oxytocin release in the SON and septum in other males, and aggressive lactation attempts on a non-lactating female rat led to oxytocin release in PVN. These results indicate that different types of stimulation cause the region-dependent nature of oxytocin release (https://www.nature.com/articles/s41380-020-0802-9).
Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.
We utilize an optimized nasal spray formulation developed at Stanford University that overcomes many of the drawbacks of conventional preservative-containing nasal sprays, while simultaneously stabilizing peptides such as oxytocin . Since our competitors do not follow this manufacturing protocol, their oxytocin peptides are susceptible to degradation and/or contamination.
PEPTIDES PREFER THE COLD
ONLY MIX WITH STERILE BACTERIOSTATIC WATER
NEVER SHAKE A VIAL TO MIX.
The most commonly adopted treatment for being overweight is lifestyle intervention, yet this is only partially effective, and most individuals who successfully lose weight fail to maintain their weight in the healthy range , . Chronic overeating—specifically the overconsumption of high-calorie foods, is a key driver of being overweight. Functional magnetic resonance imaging (fMRI) studies in overweight individuals have demonstrated increased activation of reward-related brain regions (e.g., insula, amygdala, orbitofrontal cortex, and striatum) that drive overindulgence of foods in the absence of a real need for caloric intake, when men and women view pictures of highly palatable foods –.
When palatable foods are highly accessible, hyperresponsivity of reward brain regions contribute to the development and maintenance of being overweight , and therefore it is sensible to therapeutically target the neurobiological reward pathways involved. Fortunately, fMRI studies have shown that oxytocin nasal sprays decrease unnecessary food intake in humans by correcting faulty nutrient status signaling in the brain (ie. if you don’t need calories you won’t crave calories) , .
Incredibly, researchers demonstrated that in overweight individuals following a single nasal spray dose of 24 IU of oxytocin compared with placebo, those who viewed high-calorie food stimuli vs. nonfood stimuli demonstrated reduced stimulation to high-calorie food , . This study revealed that oxytocin can literally rewire your brain, almost immediately, to be less stimulated by pictures of high-calorie food, leading to reduced food intake subsequently.
Other similar studies in humans showed that a single morning dose of intranasal oxytocin compared with placebo reduced total caloric intake at breakfast , reduced consumption of chocolate cookies  as well as chocolate biscuits and salty crackers . In the last study, the test subjects were healthy young men, demonstrating that the weight loss benefits of oxytocin are not restricted to overweight individuals.
Whole body energy expenditure
In addition to reducing energy intake by limiting food craving and enhancing cognitive control of eating, oxytocin has an important role in modulating energy expenditure and body composition. In fact, multiple studies have revealed that nasal spray oxytocin produced more weight loss than would be expected based on its impact on food intake alone .
In a study of diet-induced obesity, oxytocin treatment produced weight loss even when food intake was not altered , and numerous studies have also indicated that oxytocin-mediated weight loss is maintained even after its effects on food intake have returned to baseline . This is particularly interesting when you consider that while oxytocin appears to increase resting energy expenditure, it does not appear to directly increase spontaneous physical activity .
Anabolic effect in muscle
Contemporary research has started to focus on how oxytocin works with sex steroid hormones to produce anabolic growth in muscle. In overweight individuals, preservation of oxytocin signaling is associated with anabolic benefits for both muscle and bone. On the other hand, when oxytocin signaling declines, as occur in metabolic disorders, insufficient oxytocin leads to adverse effects on both muscle and bone health .
Recently, researchers made the unexpected discovery that oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration . Further insights came from studies of older individuals, in which the researchers focused on the reduced muscle regeneration and muscle atrophy (ie. sarcopenia) occurring in aging. While it is well known that aging is accompanied by reduced physiological levels of sex steroids, this study revealed found circulating oxytocin level is also reduced in older individuals . Ongoing research is now evaluating how exercise-mediated increases in oxytocin could ultimately contribute to maintaining muscle homeostasis and add to the additional benefits of exercise, including an increased life span and general well-being .
Anxiety & stress-reduction
Oxytocin administration holds promise for acting in areas that are central to relationship health and functioning. Specifically, oxytocin has been shown to reduce anxiety and stress. In one study, cortisol was reduced following oxytocin nasal spray administration . In another set of studies, oxytocin was shown to mediate a decrease in anxiety associated with sexual activity –.
However, it should be noted that under non-sexual and stress-free conditions (and thus low oxytocin signaling), there does not seem to be an anti-anxiety effect of oxytocin. Thus, oxytocin does not seem to play a major role in the maintenance of a basal level of anxiety, but rather comes into play during psychosocial or physiological activation of the neurobiological system.
Safe, natural, non-toxic & well-tolerated.
Oxytocin has been the subject of dozens of clinical trials, and it has been tested in thousands of individuals ranging from children to adults. The safety of nasal spray oxytocin in adults has been extensively reviewed from a collection of studies with over 1500 total individuals . No reproducible side effects have ever been observed in short-term studies of doses of 18–40 IU per day. In at least 1 long term adult study with 59 patients, participants received 40 IU 2 times per day for 13 weeks, representing a large net exposure, yet no adverse effects were observed .
In a weight loss study in adults, patients were administered 24 IU of oxytocin 4 times per day for 8 weeks and reported no serious adverse effects . One of the key takeaways from this massive amount of clinical research is the exceptional safety and tolerability of oxytocin, which has further strengthened calls for repurposing it for a variety of health indications. Minor side effects related to nasal sprays in general still apply, including nasal irritation and runny nose. Pregnant women should avoid oxytocin.
In summary, a multitude of studies in animals and in humans reveal that oxytocin, a hormone characterized initially for its role in social bonding, actually has broadly beneficial effects on energy balance. Oxytocin has the capacity to promote weight loss without leading to excess loss of muscle and bone, making it an excellent candidate for inclusion in strategies to promote a lean muscle aesthetic in athletes and non-athletes alike.
*This information is for educational purposes only. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Storage: Lyophilized peptide should be stored at -20°C (freezer), and the reconstituted peptide solution at 4°C (refrigerated). Do not freeze once reconstituted.
**LAB USE ONLY**
*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
|Dimensions||0.5 × 0.5 × 1 in|