Characteristics of PEG MGF

Pegylated Mechano Growth Factor (PEG MGF) is a two component anabolic peptide that is a known derivative of the compound Insulin-like Growth Factor-1 (IGF-1). IGF-1 is known to play an important role in the regulation of Growth Hormone (GH), and helps to promote the growth of bones and tissues. MGF tends to stimulate different receptors in order to drive myoblast division, resulting in increased muscle growth. Various studies have also highlighted the ability of PEG MGF to increase the amount of muscle stem cells that go on to join existing muscle cells, also resulting in increased muscle growth.

It’s important to note that PEG MGF refers to the addition of polyethylene glycol (PEG), also referred to as “pegylation”, to the peptide MGF. By itself MGF has a very short half life of approximately 5-7 minutes. However, when adding PEG to MGF the half life is drastically increased to around 48-72 hours. Since MGF is able to move through circulation for longer periods of time, the compound becomes more stable resulting in increased functionality. In addition to extending the half life, PEG does not interact with any other substance in the body and is quickly dispelled through urination. Studies examining the usage and efficacy of PEG MGF have noted that it is important to adhere to a strict dosage and timing routine in order to avoid unwanted and excessive hypertrophy in the bones and tissues (https://focalpointvitality.com/peg-mgf-peptide/).

Effects of PEG MGF on Skeletal Muscle

Muscle injuries of any degree of severity can result in a challenging healing process. However, due to its ability to improve muscle growth and muscle stem cell production, MGF has shown promise in simplifying the healing process and ensuring that muscle injuries heal properly. Research conducted by Liu et. Al determined that a decrease in macrophages could potentially cause issues when it comes to muscle regeneration and that MGF could assist in resolving this issue. That being said, the researchers decided to examine whether MGF injections following macrophage depletion could protect against any form of impaired muscular regeneration.

Mice subjects underwent muscle contusion and macrophage depletion in order for the damaged muscle to be injected with MGF. Results were measured by morphological and genetic analyses following depletion and injection. The results reported that MGF did not have a protective effect on the muscle fibers, however, MGF decreased fibrosis in the skeletal muscles. Additionally, the MGF injection led to a decrease in inflammatory cytokines, chemokines, oxidative stress factors, and metalloproteinases. This data allowed researchers to conclude that the issues surrounding muscle regeneration following macrophage depletion could potentially be exacerbated by inflammatory compounds. However, the evidence highlights that MGF is able to treat the increased inflammation levels which could ultimately lead to less disruption in terms of muscle regeneration (https://pubmed.ncbi.nlm.nih.gov/31164836/).

The hypothesis that MGF is able to effectively modulate levels of inflammatory cytokines and macrophage function is supported by the work of researchers Sun et. Al. The purpose of their study was to examine how the expression of MGF during muscular injury affects inflammation in the muscle. Skeletal muscle injury in adult male mice was induced by cardiotoxin (CTX). 1-2 days after the CTX injection expression of the Mgf gene had increased along with levels of inflammatory cytokines. The rise in these two variables coincided with an influx of macrophages and neutrophils. Due to the correlation between increased neutrophils and macrophages and heightened Mgf gene expression, the researchers were able to confirm that MGF is upregulated in cases of muscle injury and that macrophages dramatically affect MGF levels. This study concluded that the presence of MGF in cases of skeletal muscle injury and inflammation lead to an influx of macrophages and neutrophils that help in the regulation of MGF levels. These findings support the work of Liu et. Al as both of these studies have examined the roles of MGF, macrophages, and inflammatory cytokines, and how they all regulate each other. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094977/).

Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.