Description

Epitalon Peptide

CAS Number	307297-39-8
Other Names	Epithalon, Ala-Glu-Asp-Gly, UNII-O65P17785G, O65P17785G, 64082-79-7, Epithalone
IUPAC Name	(4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Molecular Formula	C₁₄H₂₂N₄O₉
Molecular Weight	390.35
Purity	≥99% Pure (LC-MS)
Material Safety Data Sheet (MSDS)	View Material Safety Data Sheet
Liquid Availability	N/A
Powder Availability	10 milligrams vial (lyophilized/freeze-dried)
Storage Condition	Store cold, keep refrigerated. Do NOT freeze.
Terms	All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

**Important Information: Each peptide comes lyophilized/freeze-dried and must be reconstituted with Bacteriostatic Water in order to be dispensable in liquid form.

Epitalon is a synthetic peptide based on the naturally-formed peptide epithalamion, typically found in the pineal gland. Epithalamion has shown to reduce the presence of various forms of tumors within mice.

A study conducted by Kossoy et. Al examined the effects that epitalon would have on female C3H/He mice. Epitalon was administered to the mice 5 times in a week over a 6.5 month experimental period. Both the experimental and control groups of mice were experiencing spontaneous tumorigenesis throughout the ovaries and mammary glands. In the ovaries, granulosa-cell tumors were found and in the mammary glands different types of ductal carcinomas were found. Following the 6.5 month experimental period, mice showed no evidence of side effects from long term supplementation of epitalon. Furthermore, treatment with epitalon showed a reduced number in metastases and in the experimental mice there was no evidence of metastases at all (https://pubmed.ncbi.nlm.nih.gov/16634527/).

In a similar study, researchers Anisimov et. Al examined the effects that epitalon had on spontaneous mammary tumors in female FVB/N HER-2/neu transgenic mice. The mice were treated with 1 microgram of epitalon for each mouse for five days in a row. Results of this study showed that overall epitalon reduced both the size and number of the present tumors. Additionally, in the mice treated with epitalon there was a reduction in size of the present lung metastases. The researchers went on to theorize that the downregulation of the HER-2/neu gene found in mammary adenocarcinoma is responsible for epitalon’s ability to inhibit the spontaneous production of mammary tumors in HER-2/neu mice (https://pubmed.ncbi.nlm.nih.gov/12209581/).

Effects of Epitalon on Female Mouse Anatomy

Epitalon is considered a strong antioxidant that could potentially be beneficial for longevity purposes. Researchers Yue et. Al examined what kind of protective effects that epitalon has on age-damaged post-ovulatory oocytes in vitro in female mice. Following oocyte collection, 0.1 mM of epitalon was added into the oocyte sample. From there, oocyte quality was evaluated at 6, 12, and 24 hours following the sample collection.

First, the results of the study showed that epitalon reduced the number of reactive oxygen series present, indicating that epitalon works as an antioxidant. Additionally the study found that during the process of cell division there were fewer spindle defects and decreased abnormalities of the cortical granules when evaluated at 12 and 24 hours. There was increased membrane potential found in the mitochondria as well as an increase in the copy number of DNA, in turn apoptosis of oocytes was decreased by hour 24 after the sample collection. Overall the study found that epitalon can delay age-related damage through regulation of mitochondrial activity as well as reactive oxygen species (https://pubmed.ncbi.nlm.nih.gov/35413689/).

Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

Epitalon is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

Epitalon – A Peptide’s Potential in Prolonging Life and Preventing Age-related Diseases

File Name	View/Download
08-31-2021-Umbrella-Labs-Epitalon-Certificate-of-Analysis-COA.pdf

VIEW CERTIFICATES OF ANALYSIS (COA)