Description

GHRP-6 PEPTIDE

 

 

 

CAS Number	87616-84-0
Other Names	GH-releasing hexapeptide 6, GH-releasing peptide-6, (D-Trp(2)-D-Phe(5))GHRP, (D-Lys)GHRP-6, GHRP, His(1)-Lys(6)-, growth hormone releasing hexapeptide, SKF 110679, BCP22655, H-His-DL-Trp-DL-Ala-Trp-D-Phe-Lys-NH2
IUPAC Name	(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[2-[[2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoylamino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
Molecular Formula	C₄₆H₅₆N₁₂O₆
Molecular Weight	873.0
Purity	≥99% Pure (LC-MS)
Liquid Availability	N/A
Powder Availability	5 milligrams vial, 10 milligrams vial (lyophilized/freeze-dried)
Storage Condition	Store cold, keep refrigerated. Do NOT freeze.
Terms	All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

**Important Information: Each peptide comes lyophilized/freeze-dried and must be reconstituted with Bacteriostatic Water in order to be dispensable in liquid form.

Watch How To Reconstitute Peptide Video Here

GHRP-6 is a growth hormone-releasing peptide that has been shown to release growth hormone (GH) in vivo in several different species. A study conducted by Rico et. Al, studied the effects of GHRP-6 in vitro in bovine somatotropes that were separated through elutriation. GHRP-6 was administered in doses from 10(-8) M to 10(-5)M as well as 10(-9)M in the pituitary cells of the cows. It was found that all doses stimulated the release of GH, however, maximal stimulation of GH was found at 10(-6)M. The effects of treatment with GHRP-6 were seen at hours 1, 2, 3, and 4 of incubation, with the exception of heifer pituitary cells which did not experience the effects at hour 1 of the incubation period (https://pubmed.ncbi.nlm.nih.gov/10494658/).

 

Effects of GHRP-6 in Preventing Cardiovascular Failure

Several studies in mice conducted from 1997 to 1999 examined the role that growth hormone-releasing peptides played in preventing heart failure. These studies were limited due to technology and resources but came to the general conclusion that GHRPs were able to prevent cardiovascular failure.

In more recent studies DCM models characterized by left ventricle dilation, wall thinning, and systolic dysfunction examine how GHRP-6 was able to combat the declining function of the left ventricle. Rats were administered doxorubicin (DX) in order to induce a DCM model of heart failure. Overall, the study found that rats treated with GHRP-6 experienced a complete prevention of heart failure and decreased mortality rate among the rats.

While it is still difficult to determine exactly why GHRP-6 is able to prevent heart failure and increase survival rate, a report by Merck Research Laboratories theorized that this occurred due to the mediation of Ca2+. When Ca2+ is triggered to release from intracellular stores there is a resulting positive inotropic effect without the possibility of eliciting a drastic change in heart rate.

 

GHRP-6 and Heart Health

Furthermore, a study conducted by Berlanga-Acosta et. Al, treated both infarcted and healthy rabbits with GHRP-6 in order to examine the effects the peptide had on the heart. Researchers treated the rabbits with 400 microg/kg of GHRP-6 through an intravenous bolus. Similar to the theory mentioned above, it was found that treatment with GHRP-6 led to a positive and transient inotropic effect on the cardiac muscle. Additionally, the study showed that when treated with GHRP-6 the ejection fraction increased by 15-20% which was confirmed through the use of echocardiography.

Belanga-Acosta et. Al conducted a similar study using porcine models that had undergone acute myocardial infarction caused by blocking the left circumflex artery. The subjects were then reperfused over a 72-hour period and it was shown that the treatment led to a reported repair of the damaged myocardium (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392015/)

Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with a 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

GHRP-6 is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

 

File Name	View/Download
07-10-2023-Umbrella-Labs-GHRP-6-Certificate-Of-Analysis-COA.pdf

 

 

VIEW CERTIFICATES OF ANALYSIS (COA)