PT-141 BREMELANOTIDE PEPTIDE 10MG VIAL

$40.99$125.99

PT-141 is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

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Description

PT-141 (Bremelanotide) Peptide

 

bremelanotide pt 141 peptide bremelanotide pt 141 peptide bremelanotide pt 141 peptide bremelanotide pt 141 peptide bremelanotide pt 141 peptide bremelanotide pt 141 peptide bremelanotide pt 141 peptide bremelanotide pt 141 peptide

 

bremelanotide pt 141 peptide

 

CAS Number 189691-06-3
Other Names Bremelanotide, UNII-6Y24O4F92S, PT141, 6Y24O4F92S, Vyleesi (TN)
IUPAC Name (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxylic acid
Molecular Formula C₅₀H₆₉N₁₅O₁₀
Molecular Weight 1040.2
Purity ≥99% Pure (LC-MS)
Liquid Availability bremelanotide pt 141 peptide 5mL liquid spray solution (includes 20 milligrams of peptide)
Powder Availability bremelanotide pt 141 peptide 10 milligrams (lyophilized/freeze-dried)
Storage Store in a dry, cool, dark place. For best preservation, store at 4°C or colder away from bright light.
Terms All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

**Important Information: Each peptide comes lyophilized/freeze-dried and must be reconstituted with Bacteriostatic Water in order to be dispensable in liquid form.

Watch How To Reconstitute Peptide Video Here

PT-141, also known as Bremelanotide, is a peptide that has been shown to have positive effects on rats and primates in helping erectile dysfunction and various other forms of sexual dysfunction. Bremelanotide is shown to be an agonist at melanocortin receptors such as MC3R and MC4R and is also considered to be a melanocyte-stimulating hormone that is an active metabolite of Melanotan II. Various studies have begun to show how melanocortins have the ability to positively or negatively affect sexual health.

Bremelanotide is derived from the peptide hormone, melanotan II. It was originally recognized that melanocyte receptor stimulators play a role in sexual behavior in the 60s when research showed that the introduction of these receptors caused arousal in male rats. From there, researchers developed analogs such as melanton I and II. Melanotan II was further specialized and reduced into the derivative Bremelanotide. Bremelanotide is meant to bind to MC3R and MC4R has been shown to increase levels of arousal in both male and female rodents through the nervous system rather than the circulatory system (https://vitality-sciences.com/peptides/pt-141-erectile-dysfunction/).

In a study conducted by Semple et. Al, rodents with a knockout melanocortin 4 receptor (MC4R) were observed to determine how levels of sexual dysfunction varied without a proper functioning melanocortin pathway. The study found that the rodents that had this knockout gene displayed increased levels of obesity, decreased libido, and an inability to copulate. In order to explain why these phenomena were occurring, researchers reintroduced MC4R into the neurocircuitry on Sim 1 neurons and oxytocin neurons.

By reintroducing MC4R to the Sim 1 neurons it was found that latency to ejaculation as well as overall changes in sexual behavior were far lower than the mice with the knockout gene. This indicates that when MC4R is expressed on Sim 1 neurons, negative changes in sexual behavior are combatted. On a similar note, when MC4R was reintroduced to the oxytocin neurons there was a similar decrease in ejaculation latency and changes in sexual behavior (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684847/).

Bremelanotide Increases Female Sex Drive in Rats

A study conducted by Molinoff et. Al, Bremelanotide was administered to primates and rats and showed a significant decrease in erectile dysfunction in the male of the species. It was shown through c-Fos immunoreactivity that systemic introduction of Bremelanotide has been shown to activate neurons found in the hypothalamus. Due to the involvement of melanocyte receptors within the hypothalamus, it is indicated that the hypothalamus is crucial to proper sexual functioning and behaviors (https://pubmed.ncbi.nlm.nih.gov/12851303/).

A study conducted by researchers from Palatin Technologies Inc. examined the effects Bremelanotide had on female rats. Prior to sexual activity, female rats exhibit certain behaviors in order to arouse the male of the species. The behaviors of each experimental group were compared to the control group of female rats. It was discovered that after administering various doses of Bremelanotide to female rats there was an overall increase in the number of different sexual behaviors they were exhibiting before copulation in a dose-dependent manner. Furthermore, the females that had received treatment with Bremelanotide were also more willing to seek out sexual activity and had more of a desire to copulate with the male rats (https://www.eurekalert.org/news-releases/837832).

Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the pin through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

PT-141 is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

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Peptide Purity Chart

bremelanotide pt 141 peptide

File Name View/Download
08-06-2023-Umbrella-Labs-PT-141-10mg-Certificate-Of-Analysis-COA.pdf bremelanotide pt 141 peptide

 

 

VIEW CERTIFICATES OF ANALYSIS (COA)

 

Additional information

Weight 1 oz
Dimensions 0.5 × 0.5 × 1 in
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