SELANK PEPTIDE LIQUID SPRAY 15ML BOTTLE 30MG/60MG

Description

Selank

 

 

 

Molecular Formula	C₃₃H₅₇N₁₁O₉
Molecular Weight	751.9
Purity	≥99% Pure (LC-MS)
Storage	Store in a dry, cool, dark place. For best preservation, store at 4°C or colder away from bright light.
Terms	Lab Use Only. This information is for educational purposes only and does not constitute medical advice.

 

Selank is a heptapeptide that is a synthetic derivative of the tetrapeptide tuftsin. Various animal studies show that Selank is able to act as an anxiolytic and an antidepressant. A study conducted by Sarkisova et. Al showed that Selank works by activating the monoaminergic systems in the brain, it helps to synthesize and release dopamine and regulate the activity of tyrosine hydroxylase. 

 

The study used inbred WAG/Rij rats that had genetic-based symptoms of depression and compared them to BALB/c mice that had symptoms of situation-based depression in order to see whether the form of depression changed the effects that Selank had on the subjects. In order to determine whether or not Selank had an effect on depression in the test subjects, the animals underwent a forced swimming test as well as had their sucrose intake measured. 

 

In high doses of 1000-2000 microg/kg, it was shown that Selank helped to reduce the symptoms of depression in the WAG/Rij rats. This was determined by their decreased sucrose intake and their increased immobilization during the forced swimming test. In low doses of 100 and 300 microg/kg, Selank was able to slightly reduce the time period of immobility in BALB/c mice but the effects were not as significant as the high doses of 600 and 900 microg/kg. Overall, the study concluded that there was enough evidence to suggest that Selank can help treat both genetic and situational causes of depression (https://pubmed.ncbi.nlm.nih.gov/18661785/).  

 

Effects of Selank on Immune Responses

In addition to its positive effects on depression, Selank has been shown to help regulate immune responses and decrease inflammation. In a study conducted by Kolomin et. Al Selank and one of its fragments, Gly-Pro, was compared against the dynamics of various inflammatory genes such as C3, Casp1, Il2rg, and Xcr1 within the spleen of a mouse. The mice were given one intraperitoneal injection of Selank at a dose of 100 microg/kg. Following the injection,  researchers found that Selank decreased C3 mRNA by three-fold only 30 minutes after the injection. Following the Selank injection, researchers reported a “wave-like” effect on the Casp1 mRNA, where levels would fluctuate back and forth. The research showed that there were significant changes made to the mRNA levels of both the Il2rg and the Xcr1 gene where expression was greatly reduced 90 minutes after the injection. 

 

Overall this study concluded that treatment with Selank leads to the regulation of many of the genes that control various immune responses in the body, which indicates that Selank may play a role in modulating the immune system (https://www.sciencedirect.com/science/article/abs/pii/S0161589013005440).  

 

Peptides Prefer the Cold

In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.

Swab the top of the vial with a 95% alcohol wipe before accessing.

Only Mix with Sterile Bacteriostatic Water

Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.

Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.

Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

 

Selank (Russian: Cеланк) is a nootropic, anxiolytic peptide based drug developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP).

Selank is a synthetic analogue of the immunomodulatory peptide tuftsin; as such, it mimics many of its effects. It has been shown to modulate the expression of Interleukin-6 (IL-6) and affect the balance of T helper cell cytokines.^[1] It has been shown to influence the concentration of monoamine neurotransmitters^[2] and induce metabolism of serotonin.^[3][4] Selank has also been found to rapidly elevate the expression of brain-derived neurotropic factor (BDNF) in the hippocampus of rats.^[5]

Selank, as well as a related peptide drug, Semax, have been found to inhibit enzymes involved in the degradation of enkephalins and other endogenous regulatory peptides, and this action may be involved in their effects.^[6] It has also been found to affect the activity of carboxypeptidase H and phenylmethylsulfonylfluoride-inhibited carboxypeptidase in rat nervous system tissue.^[7]

Selank has been found to produce antidepressant-like effects in animal models of depression and anhedonia.^[8]

Storage: Lyophilized peptide should be stored at -20°C (freezer), and the reconstituted peptide solution at 4°C (refrigerated). Do not freeze once reconstituted.

Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

 

**LAB USE ONLY**

*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

 

 

 

Additional information

Weight	1 oz
Dimensions	0.5 × 0.5 × 1 in
Size	30 Millilitres (1oz), 60 Millilitres (2oz)