Description

Semax

 

 

 

CAS Number	80714-61-0
Other Names	ACTH (4-7), Pro-Gly-Pro-ACTH (4-7), prolyl-glycyl-proline-Pro-Gly-Pro-ACTH (4-7)
IUPAC Name	(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid
Molecular Formula	C₃₇H₅₁N₉O₁₀S
Molecular Weight	813.9
Purity	≥99% Pure (LC-MS)
Liquid Availability	30mg liquid spray  90mg liquid spray
Powder Availability	5 milligrams, 30 milligrams (lyophilized/freeze-dried)
Storage  Condition	Store cold, keep refrigerated. Do NOT freeze.
Terms	All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

**Important Information: Each peptide comes lyophilized/freeze-dried and must be reconstituted with Bacteriostatic Water in order to be dispensable in liquid form.

Watch How To Reconstitute Peptide Video Here

Effects of Semax on Dopamine Expression

Semax is a heptapeptide that is considered to be an analog of the N-terminal fragment of adrenocorticotropin that has been shown to have various neuroprotective effects examined through several animal-based studies.

A study conducted by Levitskaya et. Al examined the effects Semax has on dopaminergic systems in the brain. White rats were given the neurotoxin MPTP in order to induce lesions on the dopaminergic centers. MPTP was given to the rats in 25 mg/kg doses and was shown to cause an increase in anxiety and a decrease in activity in the rats. Following the administration of the neurotoxin MPTP, the rats were given Semax at doses of 0.2 mg/kg. The study concluded that this dose of Semax greatly reduced the effects of the lesions caused by the neurotoxin. Overall, Semax acted in a protective manner against the lesions in the dopaminergic centers of the brain (https://link.springer.com/article/10.1023/B:NEAB.0000018752.59465.28).

 

Effects of Semax on Anxiety and Depression

As the positive benefits that Semax has on dopamine expression have already been discussed, further studies have built on that research to draw conclusions and perform studies on the effects Semax has on anxiety and depression.

In a study conducted by Leviskaya et. Al, rats were observed in a control group and in a group receiving treatment with cholecystokinin-tetrapeptide (CCK-4). Before administering the CCK-4, rats were administered Semax in doses of 50 and 500 microg/kg. 15 minutes after administration of Semax, the rats were given CCK-4 in doses of 400 microg/kg. Injection of CCK-4 caused increased levels of anxiety and depression in the rats which were confirmed through maze tests and forced swimming tests, respectively. In the rats treated with both CCK-4 and Semax it was found that administration of Semax reduced and normalized the neurodivergent behavior the rats were exhibiting, indicating that it could play a role in reducing levels of anxiety and depression when levels are elevated (https://link.springer.com/article/10.1134/S1062359010020147).

 

Effects of Semax on Experimental Ischemia

In addition to its effects on dopaminergic centers of the brain, Semax has also been shown to positively affect the morphology of cells within the nervous system that was damaged by ischemia in rats. A study conducted by Stavchansky et, Al showed that when treating the rats with Semax the capillary network was activated. This led to increased proliferation of blood vessel endothelium, neuroglia, and various different progenitor cells. Additionally, Semax was able to reduce the effects of ischemia in the brain and lessen the damage to the nervous tissue (https://link.springer.com/article/10.1007/s12031-010-9421-2).

A similar study conducted by Yakovleva et. Al found similar results as the previous experiment. The study examined the effects that Semax has on overall ischemia in the cerebral portion of the brain that was caused by occlusion of the carotid arteries. It was found that administering Semax to animals experiencing this type of ischemia led to an improvement in neurological functioning and survival of the neurons following the onset of ischemia (https://link.springer.com/article/10.1007/BF02433821).

Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with a 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

Semax is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

 

 

File Name	View/Download
10-10-2023-Umbrella-Labs-Semax-Certificate-Of-Analysis-COA.pdf

 

 

VIEW CERTIFICATES OF ANALYSIS (COA)

 

 

Additional information

Weight	1 oz
Dimensions	0.5 × 0.5 × 1 in
Options	30 Milligrams Peptide Vial, 5 Milligrams Peptide Vial, 90 Milligrams Liquid Spray, 30 Milligrams Liquid Spray