Sermorelin is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

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sermorelin peptide


Molecular Formula C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular Weight 3357.9
Purity ≥99% Pure (LC-MS)
Storage Store in a dry, cool, dark place. For best preservation, store at 4°C or colder away from bright light.
Terms Lab Use Only. This information is for educational purposes only and does not constitute medical advice.


What is Sermorelin

Sermorelin is a synthetic peptide that acts as a growth hormone-releasing hormone (GHRH) and prompts the release of Growth Hormone (GH) from the anterior pituitary gland. Sermorelin is clinically referred to as (GHR)1-29 NH2 indicating that the amino terminus is found at the 29th position. However, in clinical settings sermorelin is not used as a free base, but rather as an acetic acid salt. Treatment with sermorelin has been shown to increase serum concentration levels of GH and insulin-like growth factor (IGF-1). 

Without supplementation of sermorelin, there are existing positive and negative feedback loops regulating the secretion of GH and somatostatin. This in turn creates a cycle similar to a circadian rhythm of GH secretion. With supplementation of sermorelin, the amplitude and frequency of GH secretion are drastically improved. 


Effects of Sermorelin on Sleep Patterns and Orexin 

Various animal studies have shown that there is a potential link between supplementation of sermorelin and sleep patterns. These studies have shown that sermorelin is known to increase slow-wave sleep which is when the rate of GH secretion is at its highest level. As these animals aged they showed decreased levels of slow-wave sleep as well as a 2 to 3-fold decrease in GH secretion, indicating that there is a link between GH secretion and the amount of slow-wave sleep. 

Additionally, sermorelin has also been shown to affect orexins, the neurons in charge of regulating the sleep-wake cycle in animals. Due to the role of orexins in homeostasis, it has been hypothesized that orexins are regulated by the GH-axis. Dysfunctions of the orexins are related to both obesity and sleep disorders such as narcolepsy due to the overstimulation of the orexin receptors. It’s indicated that orexin plays a vital role in GH secretion, which is supported by the link between slow-wave sleep and GH secretion mentioned above. Animal studies have also shown that administration of sermorelin stimulates levels of orexins and indirectly improves levels of GH secretion ( 


Effects of Sermorelin on Growth Delays

It has been established that sermorelin has been shown to play a role in the regulation and function of the GH-axis and secretion of GH. Sermorelin has a short half-life of only 11-12 minutes. This allows sermorelin to be administered either intravenously or subcutaneously and promotes GH secretion from the pituitary gland without affecting other hormones such as insulin, cortisol, glucose, glucagon, luteinizing hormone, or follicle-stimulating hormone.

Due to the stability of the previously listed hormones when sermorelin is administered, clinical studies were approved to begin testing on infantile mammals experiencing growth delays. The studies showed that within 6 months there was a drastic increase in the release of GH. Clinical studies will soon be moving into examining the effects that sermorelin has on muscle wasting and cognition in elderly mammals as well as lipodystrophy caused by HIV ( 


Peptides Prefer the Cold

In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.

Swab the top of the vial with a 95% alcohol wipe before accessing.

Only Mix with Sterile Bacteriostatic Water

Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.

Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.

Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

Also known as GHRH (1-29), it is a peptide analogue of growth hormone-releasing hormone (GHRH) which is used as a diagnostic agent to assess growth hormone (GH) secretion for the purpose of diagnosing growth hormone deficiency. It is a 29-amino acid polypeptide representing the 1–29 fragment from endogenous human GHRH, thought to be the shortest fully functional fragment of GHRH.

Sermorelin Peptide is under active investigation in a number of cell culture and animal models.
Our Sermorelin Peptide is stored and handled according to industry guidelines to ensure stability.


Keep peptide vials refrigerated at all times to reduce peptide bond breakdown. DO NOT FREEZE. Most peptides, especially shorter ones, can be preserved for weeks if careful.
Always swab the top of the vial with an alcohol wipe, rubbing alcohol or 95% ethanol before use.
Before drawing solution from any dissolved peptide vial, fill the pin with air to the same measurement you will be filling with solution, ie. if you plan to take 0.1 ml, first fill the pin with 0.1ml of air, push the air into the vial, and then draw the peptide back up to the 0.1 ml marker. Doing so will maintain even pressure in the vial. Always remember to remove air bubbles from the pin by flicking it gently, needle side up, and pushing bubbles out. In addition, push out a tiny amount of solution to ensure there is no air left in the metal tip.


The purity and sterility of bacteriostatic water are essential to prevent contamination and to preserve the shelf-life of dissolved peptides.
Push the pin through the rubber stopper at a slight angle, so that you inject the bacteriostatic water toward the inside wall of the vial, not directly onto the powder.
Lyophilized peptide should be stored at -20°C (freezer), and the reconstituted peptide solution at 4°C (refrigerated). Do not freeze once reconstituted.


Air bubbles are unfavorable to the stability of proteins.


*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).



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Peptide Purity Chart

sermorelin peptide

File Name View/Download
12-23-2022-Umbrella-Labs-Sermorelin-2mg-Certificate-Of-Authenticity-COA.pdf sermorelin peptide






Additional information

Weight 1 oz
Dimensions 0.5 × 0.5 × 1 in
Molar Mass

3357.93 g·mol−1

Molecular Formula