Effects of Thymalin and Immune Function

Thymalin is a polypeptide that can be used for various dysfunctions within the immune system such as immune depression and infections caused by bacteria and viruses. Thymalin was first synthesized by researchers Morozov et. Al from the thymus of calves and has since shown promise in combating apoptosis and regulating regeneration and hematopoiesis. Additionally, the chemicals immunoprotective success is based on the restoration of T and B lymphocytes and the resulting increase in activity. In a study conducted by Khavinson et. Al, researchers examined the effects of thymalin as well as its peptide components, EW peptide, the dipeptide KE, and the tripeptide EDP.
In the study conducted, Khavinson et. Al found that the short peptide components EW, KE, and EDP were most likely to activate and differentiate the immune response, decrease rates of apoptosis, and increase the viability of immune cells.

Thymalin, Thymogen and Postoperative Healing

First, the short peptide, EW, also referred to as thymogen, was shown to be quite similar to thymalin and could be considered very beneficial in preoperative and postoperative situations. Various studies conducted with thymogen found that preoperative treatment restored both functional and structural parameters of immunity. Postoperative treatment led to a drastic decrease in various types of postoperative complications. Thymogen was also shown to have “geroprotective properties” in numerous animal experiments, for example, treatment with thymogen in rats led to a 1.5-fold decrease in tumor and an overall increase in survival rates (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365293/).

Next, the short dipeptide, KE, also referred to as Vilon, was shown to activate macrophages, blood lymphocytes, thymocytes, and neutrophils. It was also shown to stimulate cellular immunity. One of the main benefits of treating with the KE dipeptide is that it assists the expression of CD4 and CD5 on thymus cells, in turn, this stimulates the differentiation of T helper cells. Additionally, a 2009 study conducted by Khavinson et. Al was cited and described how introducing the KE dipeptide to transgenic mice suppressed HER-2/neu oncogene expression by 2-fold. Overall, the KE dipeptide displayed many benefits such as increasing proportions of euchromatic, decreasing heterochromatin levels, and regulating telomere length (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365293/).

Finally, the EDP tripeptide was tested in the thymic cells of rats exposed to gamma irradiation, leading to accelerated aging. Following the administration of EDP, the rats maintained the cortex-medulla division which indicates the animal was not subject to aging. Additionally, administration of EDP led to an increase in mast cells and macrophages as well as an increase in the proliferation of thymocytes. Overall, the study found that EDP stimulated various cells of the immune system, led to the proliferation of epithelial cells, and prohibited the synthesization of tumor K-562 cells (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365293/).

Comparative studies were performed examining the effects thymalin and the short peptide complexes had on immunogenesis by taking spleen tissue cultures of both young and old mice. Following administration of the short peptides EW, KE, and EDP there were notable changes in both apoptosis levels and proliferation rate. Overall the short peptide complexes led to an increase in cell proliferation, a 20-50% increase in the growth index, and a 29-42% reduction in apoptosis. Thymalin supplementation led to even more drastic results potentially due to the presence of all three of the short peptides (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365293/).

Peptides Prefer the Cold
In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE.
Swab the top of the vial with a 95% alcohol wipe before accessing.
Only Mix with Sterile Bacteriostatic Water
Bacteriostatic water is vital to preventing contamination and preserving the stability of the compound.
Push the needle through the stopper at an angle in order to direct the stream to the side of the vial.
Reconstituted peptide solution should be stored at around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius.

Thymalin is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.