SARMS for Sale: RAD 140 SARM TESTOLONE – 20MG/ML – 30ML/60ML BOTTLE
$70.99 – $154.98
RAD 140 SARM
RAD 140 SARM is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.
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Description
RAD-140 SARM For Sale
How To Purchase RAD 140 Testolone SARM?
| CAS Number | 1182367-47-0 |
| Other Names | Testolone, RAD140, RAD 140, Vosilasarm, 4O87Q44KNC, CHEMBL1672635, D09ZLZ |
| IUPAC Name | 2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile |
| Molecular Formula | C₂₀H₁₆ClN₅O₂ |
| Molecular Weight | 393.8 |
| Purity | ≥99% Pure (LC-MS) |
| Liquid Availability |  30mL liquid Glycol (20mg/mL, 600mg bottle)
|
| Powder Availability |  1 gram |
| Gel Availability |  20 milligrams |
| Storage | Store in cool dry environment, away from direct sunlight. |
| Terms | All products are for laboratory developmental research USE ONLY. Products are not for human consumption. |
What is RAD -140?
RAD 140 SARM, or (2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile, also known as testolone was originally synthesized for Radius Health Inc. in conjunction with researchers from the University of Illinois, Obiter Research, and Cambridge Major Laboratories.
What is SARM?
Selective Androgen Receptor Modulators (SARMs) are a class of therapeutic compounds that have similar properties to anabolic agents, but with reduced androgenic properties. This property allows SARMs to benefit from the specificity of androgen receptors, tissue selectivity, and the lack of steroid-related side effects. They have the potential to bring the same benefits as traditional anabolic-androgenic steroids such as testosterone (increased muscle mass, fat loss, and bone density), all the while minimizing potential undesired side effects. SARMs interact with the same pathways as anabolic steroids but are selective in their action, targeting only muscle and bone cells instead of affecting all cells, including those in organs. As such, they present an advantage over steroids, although their use is still under research and they are not yet approved by the FDA for medical use.
What Are RAD 140 Effects on Animal Body Mass?
Per the initial paper detailing the synthesis and preliminary findings of the compound, RAD140 has the stability to (t1/2 >2 h) in incubations with rat and monkey microsomes, as well as a high affinity for the androgen receptor (Ki = 7 nM), approximately 4 times the affinity than that of testosterone itself. At the same time, the nearest hormone receptor activated by RAD140 was progesterone at a level of 750nM.
The earliest primate studies on RAD-140 indicated that even at the lowest dose range 0.1mg/kg, juvenile macaques gained a mean of ten percent in body weight, during the 28-day trial period, which was primarily confirmed to be lean body mass via DEXA scans performed before and after the trial period, however, this was somewhat variable.
What Are RAD 140 Effects on Neurons?
In a study conducted by Jayaraman et. Al, gonadectomized, male rats were studied to see the effects supplementation with RAD 140 had in regards to neuroprotection in order to make conclusions regarding the usefulness of SARMs against neurodegenerative disorders.
The rats were orally provided with 1 mg/kg a day of RAD 140 for 2 weeks. It was found that RAD140 was able to reduce apoptosis caused by Aᵝ, apoptosis activator II, and hydrogen peroxide by a significant amount. This is due to the role MAPK signaling plays in neuroprotection.
Aᵝ was by far the most potent of the apoptosis insults introduced to the rats. After 24 hours of exposure to Aᵝ, 50% of viable neurons in the rats had decreased, however, when given RAD 140 in a concentration-dependent matter, the viability of the neurons had increased exponentially. The most effective concentration of RAD 140 was 100 nM, which led to approximately 90% neuron survival after Aᵝ exposure (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959610/).
In addition to measuring the neuroprotection against various apoptosis insults, researchers also measured the effects RAD 140 had on kainate-induced neuron death. It was found that when compared to treatment with a vehicle, kainate-induced neuron death was significantly reduced (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959610/).
Our compounds are available in powdered, poly-cell, and standard polyethylene glycol formulations. We employ an amphiphilic copolymer to form polymeric micelles that enhance the bioavailability of select SARMs in animal models.
Furthermore, our nano-emulsification process ensures minimum polymeric micelle size and variance. However, we do offer the original PEG formula for researchers who prefer the standard research delivery method.
What Is The Purity of RAD 140 From Umbrella Labs?
It is above 99% purity. The primary concern for SARM researchers today is product purity. Umbrella Labs insures and guarantees its product purity by incorporating a process of Independent testing using Mass Spectrometry and Ultraviolet Radiation. Certificates of our product Independent tests are posted with our product descriptions. Not only are our products guaranteed pure, but they are also guaranteed to be accurately concentrated as well.
**LAB USE ONLY**
*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
RAD 140 SARM is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.
RAD-140 (Vosilasarm) – Emerging Research And Clinical Insights
| File Name | View/Download |
| 05-16-2023-Umbrella-Labs-RAD-140-Testolone-Certificate-Of-Authenticity-COA.pdf |  |
VIEW CERTIFICATES OF ANALYSIS (COA)
Additional information
| Weight | 4 oz |
|---|---|
| Dimensions | 3 × 3 × 5 in |
| Formula Option | |
| CAS Number | |
| PubChem CID | |
| ChemSpider ID | |
| Molar Mass | 393.83 g·mol−1 |
| Molecular Formula | C20H16ClN5O2 |
| Size |
