S-4 Andarine SARM is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

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S-4 Andarine SARM



Molecular Formula C₁₉H₁₈F₃N₃O₆
Molecular Weight 441.4
Purity ≥99% Pure (LC-MS)
Storage Store in cool dry environment, away from direct sunlight.
Terms Lab Use Only. This information is for educational purposes only and does not constitute medical advice.


S-4 is a SARM more commonly known as Andarine, also has been called Androxolutamide and GTx-007. In a fascinating study conducted by Gao et. Al, S-4 was characterized as an androgen receptor agonist in orchidectomized rats, with the mechanism of action in the skeletal muscle, bones, and pituitary.

S-4 Effects on Muscle Mass

Male rats were treated with either 3 mg/kg or 10 mg/kg of S-4 12 weeks after castration over an 8 week period. The study showed that both the 3 mg/kg dose and 10 mg/kg dose were successful in restoring both muscle mass and strength in the soleus muscle as well as muscle mass in the levator ani muscle comparable to that of intact male rats (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039881/).

Treatment with S-4 also minimally impacted the weight of the prostate and the seminal vesicles by approximately 16-17%, however, the S-4 treatment had strong androgenic effects on the prostate and seminal vesicles.

Furthermore, both the 3 mg/kg dose and the 10 mg/kg dose demonstrated strong agonist activity in the pituitary by decreasing plasma levels of both luteinizing hormone (LH) and follicle-stimulating hormone (LSH) in the castrated male rats (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039881/).

S-4 Effects on Bone Mineral Density

According to the study by Gao et. Al, treatment with S-4 over an 8-week course showed that there was a significant increase in bone mineral density in castrated male rats.

In a study conducted by Kearbey et. Al, female Sprague-Dawley rats were treated to see the effects of the SARM on the accelerated bone loss caused by ovariectomy. This study concluded that the S-4 treatment maintained cortical content and overall bone mineral density, as well as increased bone strength while also decreasing overall body fat (https://pubmed.ncbi.nlm.nih.gov/17063395/).

Additionally, the study conducted by Kearbey et Al. came to the overall conclusion that S-4 treatment has positive effects on skeletal muscle and bones. It was suggested the S-4 treatment could reduce instances of fracture by both increasing bone mineral density and strengthening bones, as well as strengthening skeletal muscles which reduce the probability of falls (https://pubmed.ncbi.nlm.nih.gov/17063395/).

Where to Buy S-4

Our compounds are available in powdered, poly-cell, and standard polyethylene glycol formulations.  Amphiphilic copolymer + coconut MCT oil to form polymeric micelles that enhance the bioavailability of select SARMs.

Furthermore, our nano-emulsification process ensures minimum polymeric micelle size and variance. Most importantly, our Poly-Cell Formula TM is optimized for sublingual absorption with a minimal taste profile. This stands in contrast to PEG, which is often intolerable for sublingual delivery due to its very unpleasant taste, leading to poor compliance among animal research participants.

The primary concern for SARM researchers today is where to buy SARMS that are reliable and consistently pure. Umbrella Labs insures and guarantees its product purity by incorporating a process of Independent testing using Mass Spectrometry and Ultraviolet Radiation. Certificates of our product Independent tests are posted with our product descriptions.



*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).


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S4 Andarine Certification of Authenticity COA

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Additional information

Weight 4 oz
Dimensions 4 × 4 × 2 in
Formula Option


CAS Number‎

PubChem CID


ChemSpider ID

Molar Mass

441.363 g·mol−1

Molecular Formula