GW-0742 – 20MG/ML – 30ML/60ML BOTTLE
$69.99 – $153.98
GW-0742 SARM is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.
- Additional information
|Purity||≥99% Pure (LC-MS)|
|Storage||Store in cool dry environment, away from direct sunlight.|
|Terms||Lab Use Only. This information is for educational purposes only and does not constitute medical advice.|
A next-gen PPAR activator making waves in the SARM research community.
GW-0742 is a SARM that is more commonly categorized as an agonist of selective peroxisome proliferator-activated receptors (PPARs). PPARs have been shown to be involved in the metabolism of lipids and carbohydrates as well as playing a role in the regulation of metabolic homeostasis and reduction of inflammation.
Effects of GW-0742 on Insulin and Glucose Levels
In a fascinating study by Niu et. Al, male Wister rats that weighed between 260 and 280 grams were given a high fructose diet to see the effect GW-0742 has on blood glucose levels and levels of insulin resistance.
The rats in this study were fed a 60% fructose-rich food that induced type 2 diabetes and insulin resistance, over the span of two months. During this time period, both plasma glucose and plasma insulin levels rose considerably. From there, the levels of glucose and insulin sensitivity were used to measure the efficacy of supplementation with GW-0742. Following supplementation, it was found that by injecting rats with GW-0742 when in a metabolically challenged state. This resulted in increased insulin sensitivity and glucose levels lowered drastically (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610778/).
Effects of GW-0742 on Fuel Utilization
Similarly, in a study conducted by Constantin et. Al, male Wister rats were used to test the effects of GW-0742 on fuel utilization in the body.
The rats were given either a vehicle or active GW-0742 over the course of 6 days at doses of either 5 mg/kg or 100 mg/kg. After dosing the mice with GW-0742, it was shown that over the course of intake, fuel pathways in the body shifted from using high amounts of carbohydrates to using lipid oxidation due to increased protein expression as well as increased PDK mRNA (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277240/).
GW-0742 and Gut Injury and Inflammation
In a study conducted by Di Paola et. Al, the effects of GW-0742 were measured in regards to gut ischemia and repercussion injury or IRI in the intestines of mice. The effects were studied by clamping the superior mesenteric artery and the celiac trunk for 45 minutes and then releasing the clamps to allow for reperfusion. Five minutes before reperfusion the mice were injected with 0.1 mg/kg GW-0742 which was shown to greatly reduce mortality rate, evidence of gut injury, several inflammatory enzymes and cytokines, and apoptosis (https://pubmed.ncbi.nlm.nih.gov/20430778/).
Our compounds are available in powdered, poly-cell, and standard polyethylene glycol formulations. We employ an amphiphilic copolymer to form polymeric micelles that enhance the bioavailability of select SARMs.
Furthermore, our nano-emulsification process ensures minimum polymeric micelle size and variance. Most importantly, our Poly-Cell Formula TM is optimized for sublingual absorption with a minimal taste profile. This stands in contrast to PEG, which is often intolerable for sublingual delivery due to its very unpleasant taste, leading to poor compliance among research participants.
The primary concern for SARM researchers today is where to buy SARMS that are reliable and consistently pure. Umbrella Labs insures and guarantees its product purity by incorporating a process of Independent testing using Mass Spectrometry and Ultraviolet Radiation. Certificates of our product Independent tests are posted with our product descriptions. Umbrella Labs not only guarantees SARM purity, but also guarantees accurate solution concentration.
**LAB USE ONLY**
*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
|Dimensions||3 × 3 × 5 in|