GW-0742 POWDER – 1000MG / 1 GRAM

$69.99

GW-0742: A next-gen PPAR activator making waves in the research community

 

*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

 

References

  1. E. Barrett-Connor, “Lower endogenous androgen levels and dyslipidemia in men with non-insulin- dependent diabetes mellitus,” Ann. Intern. Med., 1992.
  2. G. Tibblin, A. Adlerberth, G. Lindstedt, and P. Björntorp, “The pituitary-gonadal axis and health in elderly men: A study of men born in 1913,” Diabetes, 1996.
  3. S. M. Haffner, J. Shaten, M. P. Stern, G. D. Smith, and L. Kuller, “Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men,” Am. J. Epidemiol., 1996.
  4. R. K. Stellato, H. A. Feldman, O. Hamdy, E. S. Horton, and J. B. Mckinlay, “Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: Prospective results from the Massachusetts Male Aging Study,” Diabetes Care, 2000.
  5. J. Y. Oh, E. Barrett-Connor, N. M. Wedick, and D. L. Wingard, “Endogenous sex hormones and the development of type 2 diabetes in older men and women: The Rancho Bernardo Study,” Diabetes Care, 2002.
  6. D. E. Laaksonen et al., “Testosterone and Sex Hormone-Binding Globulin Predict the Metabolic Syndrome and Diabetes in Middle-Aged Men,” Diabetes Care, 2004.
  7. E. B. Geer and W. Shen, “Gender differences in insulin resistance, body composition, and energy balance,” Gend. Med., 2009.
  8. K. I. Birkeland, K. F. Hanssen, P. A. Torjesen, and S. Vaaler, “Level of sex hormone-binding globulin is positively correlated with insulin sensitivity in men with type 2 diabetes,” J. Clin. Endocrinol. Metab., 1993.
  9. J. T. Dalton et al., “The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: Results of a double-blind, placebo-controlled phase II trial,” J. Cachexia. Sarcopenia Muscle, vol. 2, no. 3, pp. 153–161, 2011.
  10. S. C. Kuo, P. M. Ku, L. J. Chen, H. S. Niu, and J. T. Cheng, “Activation of receptors δ (PPARδ) by agonist (GW0742) may enhance lipid metabolism in heart both in vivo and in vitro,” Horm. Metab. Res., 2013.
  11. F. M. Silva-Veiga, T. L. Rachid, L. de Oliveira, F. Graus-Nunes, C. A. Mandarim-de-Lacerda, and V. Souza-Mello, “GW0742 (PPAR-beta agonist) attenuates hepatic endoplasmic reticulum stress by improving hepatic energy metabolism in high-fat diet fed mice,” Mol. Cell. Endocrinol., 2018.
  12. M. Toral et al., “Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity,” J. Hypertens., 2015.
  13. Z. Haskova et al., “Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARβ/δ ligand GW0742,” Inflamm. Res., 2008.
  14. N. Wagner et al., “Peroxisome proliferator-activated receptor β stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin,” Cardiovasc. Res., 2009.
  15. S. A. Smith, G. R. Monteith, J. A. Robinson, N. G. Venkata, F. J. May, and S. J. Roberts-Thomson, “Effect of the peroxisome proliferator-activated receptor β activator GW0742 in rat cultured cerebellar granule neurons,” J. Neurosci. Res., 2004.
  16. A. Avogaro and S. V. De Kreutzenberg, “Mechanisms of endothelial dysfunction in obesity,” Clinica Chimica Acta. 2005.
  17. G. S. Hotamisligil, “Inflammation and metabolic disorders,” Nature. 2006.
  18. Y. X. Wang et al., “Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity,” Cell, 2003.
  19. W. R. Oliver et al., “A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport,” Proc. Natl. Acad. Sci. U. S. A., 2001.
  20. U. Risérus et al., “Activation of peroxisome proliferator-activated receptor (PPAR)δ promotes reversal of multiple metabolic abnormalities, Reduces oxidative stress, and increases fatty acid oxidation in moderately obese men,” Diabetes, 2008.
  21. C. H. Lee et al., “PPARδ regulates glucose metabolism and insulin sensitivity,” Proc. Natl. Acad. Sci. U. S. A., 2006.

 

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Additional information

Weight 2 oz
Dimensions 3 × 3 × 5 in
CAS Number‎

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