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MK-677 (Ibutamoren Nutrobal) Overview

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

[1] R. Nass et al., “Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: A randomized trial,” Ann. Intern. Med., 2008.

[2] J. Svensson et al., “Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure,” J. Clin. Endocrinol. Metab., 1998.

[3] G. P. Ceda et al., “Update on new therapeutic options for the somatopause,” Acta Biomedica. 2010.

[4] Y. O. Jeong et al., “Mk-0677, a ghrelin agonist, alleviates amyloid beta-related pathology in 5XFAD mice, an animal model of Alzheimer’s disease,” Int. J. Mol. Sci., 2018.

[5] S. M. Lee, M. H. Hong, H. Y. Chung, and M. Moon, “Ghrelin mimetic MK-677 alleviates amyloid beta-related pathology in 5XFAD mice, an animal model of Alzheimer’s disease,” Eur. Neuropsychopharmacol., 2017.

[6] M. G. Murphy et al., “Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women,” J. Clin. Endocrinol. Metab., 2001.

[7] J. T. Sigalos et al., “Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels,” Am. J. Mens. Health, 2017.

[8] I. Janssen, S. B. Heymsfield, Z. M. Wang, and R. Ross, “Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr,” J. Appl. Physiol., 2000.

[9] J. Svensson et al., “ Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure 1 ,” J. Clin. Endocrinol. Metab., vol. 83, no. 2, pp. 362–369, Feb. 1998.

[10] I. M. Chapman et al., “Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.,” J. Clin. Endocrinol. Metab., vol. 81, no. 12, pp. 4249–4257, Dec. 1996.

[11] G. Götherström, B. Å. Bengtsson, I. Bossæus, G. Johansson, and J. Svensson, “Ten-year GH replacement increase bone mineral density in hypopituitary patients with adult onset GH deficiency,” Eur. J. Endocrinol., 2007.

[12] K. Landin-Wilhelmsen, A. Nilsson, I. Bosaeus, and B. Å. Bengtsson, “Growth hormone increases bone mineral content in postmenopausal osteoporosis: A randomized placebo-controlled trial,” J. Bone Miner. Res., 2003.

[13] G. Copinschi et al., “Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men,” J. Clin. Endocrinol. Metab., 1996.

[14] H. De Boer, G. J. Blok, and E. A. Van Der Veen, “Clinical aspects of growth hormone deficiency in adults,” Endocr. Rev., 1995.

[15] R. Marcus et al., “Effects of short term administration of recombinant human growth hormone to elderly people,” J. Clin. Endocrinol. Metab., 1990.

[16] D. Rudman et al., “Effects of human growth hormone in men over 60 years old,” N. Engl. J. Med., 1990.

[17] G. Johannsson et al., “ Growth Hormone Treatment of Abdominally Obese Men Reduces Abdominal Fat Mass, Improves Glucose and Lipoprotein Metabolism, and Reduces Diastolic Blood Pressure 1 ,” J. Clin. Endocrinol. Metab., 1997.

[18] F. Salomon, R. C. Cuneo, R. Hesp, and P. H. Sönksen, “The Effects of Treatment with Recombinant Human Growth Hormone on Body Composition and Metabolism in Adults with Growth Hormone Deficiency,” N. Engl. J. Med., 1989.

[19] C. M. Ayling, B. H. Moreland, J. M. Zanelli, and D. Schulster, “Human growth hormone treatment of hypophysectomized rats increases the proportion of type-1 fibres in skeletal muscle,” J. Endocrinol., 1989.

[20] J. J. Sevigny, J. M. Ryan, C. H. Van Dyck, Y. Peng, C. R. Lines, and M. L. Nessly, “Growth hormone secretagogue MK-677: No clinical effect on AD progression in a randomized trial,” Neurology, 2008.

[21] E. J. Dhurandhar, D. B. Allison, T. van Groen, and I. Kadish, “Hunger in the Absence of Caloric Restriction Improves Cognition and Attenuates Alzheimer’s Disease Pathology in a Mouse Model,” PLoS One, 2013.

[22] N. Kunath, T. Van Groen, D. B. Allison, A. Kumar, M. Dozier-Sharpe, and I. Kadish, “Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model,” Sci. Rep., 2015.

[23] S. Madhavadas, B. M. Kutty, and S. Subramanian, “Amyloid ß lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity,” Indian J. Biochem. Biophys., 2014.

[24] H. Oakley et al., “Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer’s disease mutations: Potential factors in amyloid plaque formation,” J. Neurosci., 2006.

[25] M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa, “Ghrelin is a growth-hormone-releasing acylated peptide from stomach,” Nature, 1999.

[26] J. Su et al., “Two ghrelin receptor agonists for adults with malnutrition: A systematic review and meta-analysis,” Nutrition Journal. 2016.


Shipping Conditions: Ambient temperature.

MK-677 Ibutamoren Nutrobal Storage:  Keep in a cool and dark location.


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Additional information

Weight 2 oz
Dimensions 3 × 3 × 5 in
CAS Number‎

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