Coluracetam is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.


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Coluracetam Nootropic Liquid




CAS Number 135463-81-9
Other Names 135463-81-9, MKC-231, bci-540, UNII-V6FL6O5GR7, V6FL6O5GR7, MKC 231, D01MHI, CHEMBL37935, SCHEMBL194780, DTXSID60159386, EX-A739
IUPAC Name N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
Molecular Formula C₁₉H₂₃N₃O₃
Molecular Weight 341.4
Purity ≥99% Pure (LC-MS)
Liquid Availability 30mL liquid (80mg/mL, 2400mg bottle)
Powder Availability 1 gram, 5 grams
Gel Availability N/A
Storage Store in cool dry environment, away from direct sunlight.
Terms All products are for laboratory developmental research USE ONLY. Products are not for human consumption.


What is Coluracetam?

Coluracetam is a nootropic compound derived from the racetam family. It is most commonly known for its ability to improve overall cognitive functioning. The basic structure of coluracetam is considered a highly modified pyrrolidine backbone. Its primary mechanism of action results in an increase in high affinity choline uptake (HACU). Various studies conducted on rats examined how the concentration of coluracetam in plasma and neural tissue is affected following administration of the compound. When administering 10 mg/kg to each test subject, coluracetam was present in the plasma and the neural tissues after 30 minutes and was still detectable at the 3 hour mark. The following observations found that this data did not change even when coluracetam was supplemented daily for 7-14 days.


Coluracetam’s Effect on the Cholinergic System

Coluracetam is primarily known for its ability to regulate cholinergic neurotransmission. As it was previously mentioned, coluracetam is associated with the HACU. Choline uptake at the synapse is a crucial step in the synthesization of acetylcholine (ACh), a neurotransmitter that is heavily involved in memory retention and learning. That being said, evidence has identified disruptions in HACU functioning in subjects with Alzheimer’s Disease and dementia.

A study conducted by Takashina et. Al examined how administering coluracetam to rats with induced cholinergic dysfunction can affect the synthesizing and release of ACh, specifically in the hippocampus. The rats were split into two groups, one of which was administered the compound AF64A, to cause a drastic decrease in HACU and ACh release. Both groups were then given varying doses of coluracetam which led to the efficient reversal of these deficiencies. The findings of this study indicate that not only can coluracetam improve cholinergic functioning through increased HACU, but it can also assist in the promotion of ACh synthesis and release (

Additional studies found that coluracetam is able to improve performance on the Morris’ water maze test, specifically in mice. Following the conclusion that coluracetam led to increased HACU in mice treated with AF64A, Takashima et. Al took their research a step further. The mice treated with AF64A were subjected to the water maze test in order to conclude whether the improved HACU leads to changes in memory and learning. The data collected from this secondary study suggests that increased HACU leads to enhanced memory retention and learning as the majority of the subjects treated with AF64A saw drastic improvements in their performance on the water maze test. It’s important to note coluracetam was compared to a similar memory enhancement drug, tacrine. However, coluracetam was shown to not only be more effective but have fewer incidences of side effects (


Coluracetam’s Effect on the Glutaminergic System

Evidence has also found that in addition to increasing HACU, coluracetam is capable of regulating glutamate levels in the brain by improving the AMPA receptor potentiation. This leads to enhanced neural signaling and increased effectiveness of available glutamate. Proper functioning of AMPA receptors and glutamate neurotransmission is crucial, as these compounds are directly related to synaptic plasticity. Deficiencies of both structures are commonly found in subjects experiencing various forms of dementia and can lead to further, more severe disruptions in memory and learning abilities.

While excitatory neurotransmitters such as glutamate are essential to cognitive functions like memory retention and learning, the influx of these compounds can lead to excitotoxicity. Excitotoxicity commonly occurs when glutamate is released for a prolonged period of time, thus leading to a “cascade of neurotoxicity” that eventually results in neuronal cell death. ( However, researchers Akaike et. Al examined the potential neuroprotective effects of coluracetam that could combat cytotoxic conditions. The study that was conducted consisted of inducing glutamate neurotoxicity which was then measured by obtaining cortical cultures from feral rats.

Exposing the cultures to coluracetam led to a reduction in glutamate neurotoxicity when the cytotoxicity was induced by the calcium ionophore, ionomycin. However, there was no change in cytotoxicity when induced by nitric oxide (NO) donor, S-nitrosocysteine. This allowed the researchers to conclude that coluracetam has neuroprotective properties and is able to block NO formation caused by calcium influx (

The nootropics sold by Umbrella Labs are sold for laboratory research only. The description above is not medical advice and is for informative purposes only.

Coluracetam is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.




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