Noopept GVS-111 is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.


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Noopept GVS-111 Nootropic Powder

CAS Number 157115-85-0
Other Names Omberacetam, GVS-111, GVS 111, ethyl phenylacetyl-Pro-Gly, UNII-4QBJ98683M, 4QBJ98683M, SCHEMBL194807, CHEMBL4303687, DTXSID80166214
IUPAC Name ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate
Molecular Formula C₁₇H₂₂N₂O₄
Molecular Weight 318.4
Purity ≥99% Pure (LC-MS)
Liquid Availability 30mL liquid (30mg/mL, 900mg bottle)
Powder Availability 10 grams
Gel Availability N/A
Storage Store in cool dry environment, away from direct sunlight.
Terms All products are for laboratory developmental research USE ONLY. Products are not for human consumption.


Mechanisms and Effects of Noopept

N-phenylacetyl-l-prolylglycine ethyl ester, more commonly referred to as Noopept or GVS-111, is an ampakine nootropic closely related to the racetam compound, Piracetam. Originally discovered in 1996 by Russian pharmaceutical company JSC LEKKO Pharmaceuticals, Noopept is not considered a true racetam despite its many similarities to racetam compounds. This is due to the absence of a 2-oxo-pyrrolidine core.

Noopept typically works by increasing levels of cycloprolylglycine (CPG) in the brain. CPG is considered a dipeptide composed of proline and glycine and is shown to regulate function of the AMPA receptors and acetylcholine transmission. Ampakine nootropics have a stimulatory effect without many of the side effects that come with long term usage of stimulants. That being said, Noopept has shown promise in enhancing many aspects of cognition and reducing anxiety levels.

Noopept regulates the activity of AMPA and NMDA receptors in the brain, both of which are involved with the utilization of calcium and glutamate in the brain. Because of its ability to modulate the amount of glutamate in and between neurons, Noopept is capable of preventing glutamate toxicity. This also influences long-term potentiation and improves neuroplasticity in the brain, supporting the claim that Noopept is capable of enhancing cognition through memory retention and learning skills.

In addition to regulating AMPA and NMDA receptors, Noopept tends to increase the levels of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). Both of these compounds also work to promote neuroplasticity and help replace damaged brain cells, leading to overall better brain health and cognition. A study conducted by Ostrovskaia et. Al examined the effects of administering 0.5 mg/kg of Noopept over 28 days. The results found that this course of treatment led to a decrease in MAPKs and stress-induced kinases as well as an increase in the expression of BDNF and NGF in the hippocampus and hypothalamus of rats ( Evidence also shows that the Noopept increases alpha and beta brain waves in order to enhance neuron signaling and communication.

Noopept has also shown promise in reducing anxiety. This is primarily due to the compound’s ability to stimulate D2 and D3 dopamine receptors and acetylcholine nicotinic receptors. Furthermore, research has found that Noopept could potentially regulate various receptors throughout the serotonergic system. These qualities combined lead researchers to believe that the nootropic has the potential to improve mood and reduce anxiety.


Noopept vs Piracetam

As it was previously mentioned, Noopept is incredibly similar to the popular racetam nootropic, Pircetam. Both compounds are capable of enhancing cognition and exhibit anti-anxiety and neuroprotective qualities. Noopept and Piracetam are also involved in improving learning and memory and reducing brain damage.

The primary difference between the two nootropics comes from their potency. Noopept is considered approximately 1000 times more potent than Piracetam. Doses of Noopept range from 10-30 mg while doses of Piracetam range from 3000-4000 mg. Another key difference between the two is the extent to which they affect memory. Piracetam helps to facilitate memory retention primarily in the early stages, while Noopept is able to influence not only memory retention, but memory consolidation and retrieval as well. Noopept also has additional anxiolytic qualities than Piracetam does. This is due to Noopept’s known anti-inflammatory and antioxidant properties, as well as its ability to decrease neurotoxicity by regulating levels of glutamate and calcium (


Noopept Promotion of Learning and Memory in Lobotomized Rats

A study conducted by Ostrovskaya et. Al provides evidence for the claim that Noopept drastically affects learning and memory. The rats in the first portion of the experiment were taught an active avoidance test before undergoing a bilateral frontal lobectomy (BFL). The second portion of the experiment assessed the habituation of rats in an open field and a passive avoidance test prior to receiving a BFL.

After the BFL the rats were tested again in the active avoidance test, open field, and passive avoidance test. Results found that undergoing a BFL dramatically decreased performance on the active avoidance test, the horizontal activity in the open field was disturbed, and there was diminished latency during the passive avoidance test. Following the operation the researchers administered a 0.5 mg/kg/day of Noopept for 9 days. This method of dosage was found to drastically increase habituation of horizontal activity in the open field test as well as performance levels on both the active and passive avoidance tests (

The nootropics sold by Umbrella Labs are sold for laboratory research only. The description above is not medical advice and is for informative purposes only.

Noopept GVS-111 is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.


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