ANIRACETAM POWDER

$20.99$29.99

Aniracetam is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

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Description

Aniracetam Nootropic Powder

 

 

 

CAS Number 72432-10-1
Other Names 72432-10-1, Draganon, Sarpul, Ampamet, Ro 13-5057, Aniracetamun, Memodrin
IUPAC Name 1-(4-methoxybenzoyl)pyrrolidin-2-one
Molecular Formula C₁₂H₁₃NO₃
Molecular Weight 219.24
Purity ≥99% Pure (LC-MS)
Liquid Availability N/A
Powder Availability  60 capsules (500mg/capsule, 30 grams bottle total), 50 grams
Gel Availability N/A
Storage Store in cool dry environment, away from direct sunlight.
Terms All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

 

 

Aniracetam is a fat-soluble molecule belonging to the racetam family. Aniracetam is closely related to the popular nootropic compound, piracetam, but is often considered more effective. The differences between the two compounds stem from its structural components; aniracetam replaces piracetam’s amine group with a methylated phenyl group in order to increase fat solubility. Similar to many other racetam compounds, aniracetam is initially metabolized through the hepatic system, however, evidence shows that it is also efficiently metabolized through the gut, even in a fasted state. The compound is best known for its effects on neurotransmission as well as its ability to modulate excitatory AMPA receptors. That being said, aniracetam is being examined for its ability to treat depression and anxiety
as well as memory impairments.

Animal-based studies have examined the effects of aniracetam acting as an AMPA receptor modulator. Aniracetam works as an effective modulator of AMPA receptors through its mechanism of binding to a non-active site on the receptor. The compound then works to allosterically modify the binding site, leading to a reduced rate of desensitization when excitatory stimuli, such as glutamate, interact with the receptor. Regulation of the AMPA receptors is important to note as they drive most of the excitatory transmission in the brain. This results in accelerated amino acid transmission and improved memory retrieval skills.

Aniracetam has also shown promise in regulating the actions of kainate receptors, compounds that are closely related to the action of glutaminergic transmission and AMPA receptor activity. Kainate receptors are assembled from 5 different glutamate-related units, GluK1-5. Researchers Lowry et. Al examined how removing one of these subunits affects memory in mice. Initially, GluK4 knockout mice were subjected to a water memory maze and exhibited drastic memory acquisition and recall impairments.

These mice also showed signs of hyperactivity and impaired pre-pulse inhibition, two hallmark symptoms of schizophrenia and bipolar disorder. When comparing the GluK4 knockout mice to a wild-type control group, vast differences in memory were noticed and led researchers to believe GluK4 may also play a role in regulating psychiatric disorders. Results reported that the water maze the mice were subjected to is heavily dependent on the functioning of the hippocampus. Proper hippocampal functioning is also linked to schizophrenia and memory loss.

Evidence also suggests that both schizophrenia and bipolar disorder are related to glutaminergic transmission in the brain, specifically the activity of GluK4. This allowed researchers to conclude that neuropsychiatric disorders and neurodegeneration, such as memory loss, could potentially be caused by the improper functioning of Glu4K. However, more extensive research must be done to fully understand the transmission pathways in the brain, as well as how aniracetam could remedy these issues by acting as a positive modulator for kainate and AMPA receptors (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595388/).

Aniracetam has also shown potential in increasing levels of cholinergic and dopaminergic transmission. Dopamine and acetylcholine (ACh) are two neurotransmitters that are essential to the treatment of anxiety and depression as well as the improvement of memory retention and learning. Animal-based studies have found that aniracetam is capable of potentiating signaling of nicotinic receptors through protein interactions. Additionally, when given 50 mg/kg doses of aniracetam, rats exhibited decreased turnover rates of dopamine resulting in improved mood and memory.

Due to its ability to regulate AMPA and kainate receptors, administration of aniracetam improves neuroprotection and memory loss. A notable study conducted by Cumin et. Al induced memory and learning impairments via cholinergic antagonists, ischemia, and electroconvulsive shock. Results of this study found that doses of approximately 1.5 g can reverse the impairments and protect against new trauma. Furthermore, two different studies reported that the regulation AMPA receptor can lead to an increase in brain derived neurotrophic factor (BDNF), a compound widely known for its ability to improve neural plasticity. The stimulation protocol followed resulted in a sustained increase in BDNF levels for 5 days.

Additional studies noted aniracetam’s ability to affect neurotransmitters such as dopamine, serotonin, and ACh. When administering doses of aniracetam varying from 10-100 mg/kg, researchers noted that anxiety was drastically reduced due to the numerous interactions between the compound and the neurotransmission systems. A notable study conducted by Nakamura et. Al emphasized how the enhancement of dopaminergic signaling via aniracetam was effective at having an antidepressant effect in rat test subjects at doses of 100 mg/kg. It’s important to note that the metabolite of aniracetam, haloperidol and mecamylamine elicited these same effects (https://examine.com/supplements/aniracetam/research/#jlBkq25-overview-1).

The nootropics sold by Umbrella Labs are sold for laboratory research only. The description above is not medical advice and is for informative purposes only.

Aniracetam is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

 

 

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01-27-2023-Umbrella-Labs-Aniracetam-Certificate-Of-Analysis-COA.pdf

 

 

VIEW CERTIFICATES OF ANALYSIS (COA)

 

 

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